Abstract
In experiments on rats using an “illuminated area” avoidance test and a “threatening situation” avoidance test, preliminary i.p. administration and subsequent microinjection into the ventromedial hypothalamus of various combinations of monoamines, transmitter amino acids, and their agonists and antagonists demonstrated differences in the functional importance of the neurochemical profile of this limbic formation in mediating anxiety states of different origins. The neurochemical analysis with local intrahypothalamic administration of anxiosedative and anxioselective substances showed that the antiaversive actions of Campirone are obtained only in conditions in which the dominant motivation is fear, while chlordiazepoxide, Phenibut, and Indoter are also active in anxiety induced by negatively stressful zoosocial influences; these actions are mediated respectively by serotoninergic and GABAergic types of synaptic switching in the ventromedial hypothalamus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Ya. Buresh, M. Petran', and I. Zakhar, Electrophysiological Methods in Research [in Russian], Nauka, Moscow (1962).
V. E. Gmiro and S. E. Sendyuk, “Bis-ammonium adamantane-containing compounds - new modulators of the polyamine binding site,” Éksperim. Klin. Farmakol., 63, No. 3, 16–20 (2000).
A. N. Talalaenko, D. V. Gordienko, and O. P. Markova, “Studies of monoamine-and aminoacidergic mechanisms of the caudate nucleus in rats in producing the antiaversive effects of tranquillizers in different models of anxiety,” Ros. Fiziol. Zh. im. I. M. Sechenova, 85, No. 8, 1043–1050 (1999).
B. Cole and T. Robbins, “Dissociable effects of lesions to the dorsal or ventral noradrenergic bundle on the acquisition, performance, and extinction of aversive conditioning,” Behav. Neurosci., 101, No. 4, 476–488 (1987).
G. Flugge, “Dynamics of central nervous 5-HT1A receptors under psychosocial stress,” J. Neurosci., 15, No. 11, 7132–7140 (1995).
G. Graeff, “Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals,” Braz. J. Med. Biol. Res., 27, No. 4, 997–1088 (1994).
M. Koprowska, M. Krotewska, A. Romanuk, M. Strzelczuk, and M. Wieczorek, “Behavioral and neurochemical alterations evoked by people-chlorphenylalanine application in rats examined in the lightdark crossing test,” Acta Neurobiol. Exp., 59, No. 1, 15–22 (1999).
M. Kruk, A. Van der Poel, and W. Meelis, “Drugs and stimulationevoked hypothalamic aggression and related responses in the rat,” Psychopharmacology, 96, No. 1, 33–42 (1988).
H. Meede, S. Meki, and H. Uchimura, “Facilitatory effects of caerulin on hypothalamic defensive attack in cats,” Brain Res., 459, No. 2, 351–355 (1988).
J. Martin, E. Edwards, J. Johnson, and F. Henn, “Monoamine receptors in an animal model of affective disorder,” J. Neurochem., 55, No. 4, 1142–1148 (1990).
H. Mlani and F. Graeff, “GABA-benzodiazepine modulation of aversion in the medial hypothalamus of the rat,” Pharmacol. Biochem. Behav., 28, No. 21-22, 21–27 (1987).
M. Nazar, M. Siematkowski, A. Czlonkowska, and A. Plaznik, “The role of hippocampus in the interaction between GABA and 5-HT system in anxiety control in rats,” Pol. J. Pharmacol., 49, No. 2-3, 162 (1997).
E. Przegalinski, “Role of 5-HT1A receptors in the anticonflict activity of β-adrenergic antagonists,” Pol. J. Pharmacol., 47, No. 1, 22 (1995).
T. Sajdyk, J. Katner, and A. Shekhar, “Monoamines in the dorsomedial hypothalamus of rats following exposure to different tests of -anxiety',” Progr. Neuropsychopharmacol. Biol. Psychiatr., 21, No. 1, 193–209 (1997).
A. Shekhar, J. Hingtgen, and J. Di Micco, “GABA receptors in the posterior hypothalamus regulate experimental anxiety in rats,” Brain Res., 512, No. 1, 81–88 (1990).
A. Shekhar and J. Katner, “Dorsomedial hypothalamic GABA regulates anxiety in the social interaction test,” Pharmacol. Biochem. Behav., 50, No. 2, 253–258 (1995).
A. Valjakka, P. Riekkinen, J. Sirvio, S. Nieminen, M. Airaksinen, and R. Mauno, “The effects of dorsal noradrenergic bundle lesions on spatial learning locomotor activity and reaction to novelty,” Behav. Neural. Biol., 54, No. 3, 323–329 (1990).
H. Yokoo, M. Tanaka, A. Tsuda, T. Tanaka, and K. Mizoguchi, “Direct evidence of conditioned fear-elicit enhancement of noradrenaline release in the rat hypothalamus assessed by intracranial microdialysis,” Brain Res., 536, No. 1-2, 305–308 (1990).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Talalaenko, A.N., Pankrat'ev, D.V. & Goncharenko, N.V. Neurochemical Characteristics of the Ventromedial Hypothalamus in Mediating the Antiaversive Effects of Anxiolytics in Different Models of Anxiety. Neurosci Behav Physiol 33, 255–261 (2003). https://doi.org/10.1023/A:1022151331354
Issue Date:
DOI: https://doi.org/10.1023/A:1022151331354