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Reaction of N-Methylmorpholinium 5-Cyano-2-oxo-4-(2-thienyl)-1,2,3,4-tetrahydropyridine-6-thiolate with α-Bromo Ketones

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Abstract

Treatment of N-methylmorpholinium 5-cyano-2-oxo-4-(2-thienyl)-1,2,3,4-tetrahydropyridine-6-thiolate with α-bromo ketones in ethanol gives a 1:1 mixture of the corresponding 6-alkylthiopyridines and thiazolo[3,2-a]pyridines which are used in the synthesis of substituted 1-acyl-6-alkylthiopyridines and thieno[2,3-b]pyridines.

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Authors and Affiliations

  1. Eastern-Ukraine State University, Lugansk, 91034

    S. G. Krivokolysko

  2. Institute of Organic Chemistry, Ukraine National Academy of Sciences, Kiev-, 94

    E. B. Rusanov

  3. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 117913, Russia

    V. P. Litvinov

Authors
  1. S. G. Krivokolysko
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  2. E. B. Rusanov
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  3. V. P. Litvinov
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Krivokolysko, S.G., Rusanov, E.B. & Litvinov, V.P. Reaction of N-Methylmorpholinium 5-Cyano-2-oxo-4-(2-thienyl)-1,2,3,4-tetrahydropyridine-6-thiolate with α-Bromo Ketones. Chemistry of Heterocyclic Compounds 38, 1397–1405 (2002). https://doi.org/10.1023/A:1022146913665

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  • DOI: https://doi.org/10.1023/A:1022146913665

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