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Phenotypic Expression of the Mutant Gene diabetes insipidus in Rats and Criteria of Genotyping by Phenotype

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Abstract

The autosomal semidominant mutant gene di(diabetes insipidus) is manifested in homozygotes in the form of diabetes insipidus with water consumption from 25 to 100% of body weight per day. The heterozygotesdi/+ drink water at a rate higher than 5% but lower than 25%. The level of water consumption in rats with +/+ genotype does not exceed 5% of body weight per day. Segregation analysis of F1 animals yielded by various crosses showed that genotyping of di/di homozygotes is absolutely reliable at 30% and higher level of the water consumption per day.

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References

  1. Valtin, H., The Discovery of the Brattleboro Rat, Recommended Nomenclature, and the Question of Proper Controls, Ann. N. Y. Acad. Sci., 1982, vol. 394, pp. 1-9.

    Google Scholar 

  2. Schmale, H. and Richter, D., Single-Base Deletion in the Vasopressin Gene Is the Cause of Diabetes Insipidus in Brattleboro Rats, Nature, 1984, vol. 308, pp. 705-709.

    Google Scholar 

  3. Schmale, H., Fehr, S., and Richter, D., Vasopressin Biosynthesis—from Gene to Peptide Hormone, Kidney Int., 1987, vol. 32, pp. 8-13.

    Google Scholar 

  4. Saul, G.B., Garrity, E.B., Benirschke, K., and Valtin, H., Inherited Hypothalamic Diabetes Insipidus in the Brattleboro Strain of Rats, J. Hered., 1968, vol. 59, pp. 113- 117.

    Google Scholar 

  5. Festing, M.F.W. and Staats, J., Standardized Nomenclature for Inbred Strains of Rats, Transplantation, 1973, vol. 16, pp. 221-245.

    Google Scholar 

  6. Dlouga, G., Krshechek, I., and Natochin, Yu.V., Ontogenez pochki (Ontogeny of the Kidney), Leningrad: Nauka, 1981, pp. 1-184.

    Google Scholar 

  7. North, W.G., LaRochelle, F.T., Hardy, J., and Hardy, G.R., Radioimmunoassays for Individual Rat Neurophysins, J. Endocrinol., 1983, vol. 96, pp. 373-386.

    Google Scholar 

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  1. Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    I. I. Khegai

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  1. I. I. Khegai
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Khegai, I.I. Phenotypic Expression of the Mutant Gene diabetes insipidus in Rats and Criteria of Genotyping by Phenotype. Russian Journal of Genetics 39, 57–60 (2003). https://doi.org/10.1023/A:1022022927757

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  • DOI: https://doi.org/10.1023/A:1022022927757

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