Abstract
We demonstrated selective activation of caspases in the thymus during heat shock, i.e. primary activation of initiator caspase 9 (but not caspase 8) and effector caspase 3 (but not caspase 6). Preadaptation to heat improved animal survival after heat shock and reduced heat shock-induced activation of both initiator and effector caspases. Hence, adaptation to heat produced an antiapoptotic effect, which was not selective towards receptor-dependent or mitochondrial pathway of the caspase cascade activation.
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Kruglov, S.V., Baida, L.A., Pshennikova, M.G. et al. Adaptation to Heat Limits Stress-Induced Activation of Caspases in the Thymus. Bulletin of Experimental Biology and Medicine 134, 321–324 (2002). https://doi.org/10.1023/A:1021983525785
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DOI: https://doi.org/10.1023/A:1021983525785