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In Vitro Response of Mitochondrial Succinate Oxidase System to Epinephrine in Human Blood Lymphocytes from Health Individuals and Patients with Neurocirculatory Dystonia

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Abstract

Activities of succinate dehydrogenase (SDH) and α-glycerophosphate dehydrogenase (hyaloplasmic and mitochondrial: α-GPDHH and α-GPDHM) in peripheral blood lymphocytes, and the response of SDH activity to exogenous epinephrine in vitro (the epinephrine test) were studied in 20 healthy subjects and 46 patients with hypertensive neurocirculatory dystonia. Activities of SDH, α-GPDHH, and α-GPDHM in blood lymphocytes and SDH adrenoreactivity in epinephrine test were higher in patients than in healthy controls. Treatment with hypotensive agents (isradipin and pyrroxan) moderated adrenoreactivity. Phytotherapy normalized the baseline activities of succinate oxidase system and α-glycerophosphate pathway in blood lymphocytes.

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Authors and Affiliations

  1. State Research Institute of Military Medicine, Moscow

    M. V. Vasin, I. B. Ushakov, L. V. Koroleva, I. A. Lairov & S. N. Radchenko

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  1. M. V. Vasin
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  2. I. B. Ushakov
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  3. L. V. Koroleva
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  4. I. A. Lairov
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  5. S. N. Radchenko
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Vasin, M.V., Ushakov, I.B., Koroleva, L.V. et al. In Vitro Response of Mitochondrial Succinate Oxidase System to Epinephrine in Human Blood Lymphocytes from Health Individuals and Patients with Neurocirculatory Dystonia. Bulletin of Experimental Biology and Medicine 134, 393–396 (2002). https://doi.org/10.1023/A:1021976718941

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