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Photoprotective Activity of Melanin Preparations in Human Skin Exposed to UV Irradiation: Dependence on Previous Photoexposure

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Abstract

Photoprotective effects of three melanin preparations (from black yeast fungi and Sepia sp.) were studied. These preparations in aqueous solutions (5 μg/ml, dark exposure for 7 days) demonstrated high photomodification capacity upon exposure to visible light in doses of up to 1.8 kJ/m2. Preliminary exposure of these solutions to visible light in a dose of 360 kJ/m2 notably decreased the photoprotective effect of melanins during UV exposure of the skin treated with these solutions (at UV dose of 3.4 kJ/m2). This necessitates empirical selection of the dose and storage condition of melanin preparations for attaining the optimal photoprotective effect.

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Authors and Affiliations

  1. SPb-Tekhnologiya Firm, St. Petersburg

    B. A. Paramonov, I. I. Turkovskii, I. L. Potokin, N. A. Yurlova & V. Yu. Chebotarev

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  1. B. A. Paramonov
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  2. I. I. Turkovskii
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  3. I. L. Potokin
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  4. N. A. Yurlova
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  5. V. Yu. Chebotarev
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Paramonov, B.A., Turkovskii, I.I., Potokin, I.L. et al. Photoprotective Activity of Melanin Preparations in Human Skin Exposed to UV Irradiation: Dependence on Previous Photoexposure. Bulletin of Experimental Biology and Medicine 134, 366–369 (2002). https://doi.org/10.1023/A:1021960315307

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  • DOI: https://doi.org/10.1023/A:1021960315307

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