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Use of anti-inflammatory and non-narcotic analgesic drugs and risk of non-Hodgkin's lymphoma (NHL) (United States)

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Abstract

Objective: To examine whether exposures to anti-inflammatory and non-narcotic analgesic drugs are associated with risk of non-Hodgkin's lymphoma (NHL). Methods: A case–control study was conducted among women living in upstate New York. The study involved 376 cases of NHL identified through the New York State Cancer Registry and 463 controls randomly selected from the Medicare beneficiary files and New York State driver's license records. Information regarding use of common medications in the past 20 years and potential confounding variables was obtained by telephone interview. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using an unconditional logistic regression model. Results: There were non-significant increases in risk associated with ever use of cortisone injections and oral cortisone (OR = 1.44 (Cl 0.98–2.11) for injections and 1.21 (CI 0.73–2.00) for oral cortisone, although there was no clear dose–response relationship with either type. On the other hand, the risk of NHL progressively increased with the frequency of use of non-steroidal anti-inflammatory and non-narcotic analgesic drugs (NSAID/NNAD) (p-value for trend 0.008). Women who used any of these medications daily for more than 10 years had an OR of 1.90 (CI 1.01–3.57), compared with those who used it less than once a month on average. The risk associated with long-term use was most pronounced for ibuprofen, intermediate for aspirin, and least for acetaminophen. Conclusions: Because the population-attributable risk associated with NSAID/NNAD use is potentially large, our results need to be verified in further epidemiologic studies.

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Author notes

  1. Ikuko Kato

    Present address: Karmanos Cancer Institute/Department of Pathology, Wayne State University, Detroit, MI, USA

  2. Glauco Frizzera

    Present address: Department of Pathology, Weill Medical College of Cornell University, New York, NY, USA

Authors and Affiliations

  1. Department of Environmental Medicine, New York University of School of Medicine, New York, NY, USA

    Ikuko Kato, Karen L. Koenig, Roy E. Shore & Hiroko Watanabe

  2. Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI, 48201, USA

    Ikuko Kato

  3. Bureau of Chronic Disease Epidemiology and Surveillance, New York State Department of Health, Albany, NY, USA

    Mark S. Baptiste & Patricia P. Lillquist

  4. Department of Pathology, New York University Medical Center, New York, NY, USA

    Glauco Frizzera

  5. Department of Pathology, Alta Bates Summit Medical Center, Berkeley, CA, USA

    Jerome S. Burke

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  1. Ikuko Kato
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  2. Karen L. Koenig
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  8. Hiroko Watanabe
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Kato, I., Koenig, K.L., Shore, R.E. et al. Use of anti-inflammatory and non-narcotic analgesic drugs and risk of non-Hodgkin's lymphoma (NHL) (United States). Cancer Causes Control 13, 965–974 (2002). https://doi.org/10.1023/A:1021953224822

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