Abstract
We studied the effects of the synthetic peptide Livagen on activity of ribosomal genes, denaturation parameters of heterochromatin, polymorphism of structural C-heterochromatin, and variability of facultative heterochromatin in lymphocytes from old people. Livagen induced activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin, and release of genes repressed due to age-related condensation of euchromatic regions in chromosomes. Our results indicate that Livagen causes de-heterochromatinization (activation) of chromatin, which is realized via modification of heterochromatin and heterochromatinized regions in chromosomes from old people.
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Khavinson, V.K., Lezhava, T.A., Monaselidze, J.G. et al. Effects of Livagen Peptide on Chromatin Activation in Lymphocytes from Old People. Bulletin of Experimental Biology and Medicine 134, 389–392 (2002). https://doi.org/10.1023/A:1021924702103
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DOI: https://doi.org/10.1023/A:1021924702103