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Protective Effect of Enterosgel on Rat Liver lysosomes during Cytostatic treatment

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Abstract

Polychemotherapy with a complex of cytostatics (cyclophosphamide, doxorubicin, vincristine, prednisolone) induces progressive damage to hepatocyte membranes, which manifested in labilization of lysosomes and activation of lysosomal enzymes and serum transaminases. Enterosgel stabilized liver lysosomes and reduced manifestation of hepatocyte cytolysis.

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Authors and Affiliations

  1. Department of Pharmacology, Central Research Laboratory, Novosibirsk State Medical Academy, Russia

    O. R. Grek, S. V. Mishenina & A. B. Pupyshev

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  1. O. R. Grek
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  2. S. V. Mishenina
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  3. A. B. Pupyshev
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Grek, O.R., Mishenina, S.V. & Pupyshev, A.B. Protective Effect of Enterosgel on Rat Liver lysosomes during Cytostatic treatment. Bulletin of Experimental Biology and Medicine 134, 355–358 (2002). https://doi.org/10.1023/A:1021904230328

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  • DOI: https://doi.org/10.1023/A:1021904230328

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