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Effect of Mifegin on the Content of Cyclic Nucleotides in the Cervical Myometrium in Full-Term Pregnancy

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Abstract

Cervical myometrium was examined in 22 pregnant women at 39-41 weeks gestation at risk of labor abnormalities. The patients received mifegin for preparing to labor. A new component in the mechanism of mifegin effect on the uterine cervix in full-term pregnancy was revealed: mifegin elevated the content of cAMP by 50% and almost 2-fold increased the cAMP/cGMP ratio compared to the initial level.

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Authors and Affiliations

  1. Department of Molecular Pharmacology, Russian State Medical University, Russia

    P. V. Sergeev, E. N. Kareva, N. D. Gasparyan & V. V. Podval'nyuk

  2. Moscow Regional Institute of Obstetrics and Gynecology, Ministry of Health of Russian Federation, Russia

    P. V. Sergeev, E. N. Kareva, N. D. Gasparyan & V. V. Podval'nyuk

Authors
  1. P. V. Sergeev
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  2. E. N. Kareva
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  3. N. D. Gasparyan
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  4. V. V. Podval'nyuk
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Sergeev, P.V., Kareva, E.N., Gasparyan, N.D. et al. Effect of Mifegin on the Content of Cyclic Nucleotides in the Cervical Myometrium in Full-Term Pregnancy. Bulletin of Experimental Biology and Medicine 134, 349–350 (2002). https://doi.org/10.1023/A:1021900129419

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  • DOI: https://doi.org/10.1023/A:1021900129419

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