REFERENCES
Megyesi K, Kahn CR, Roth J, Gorden P: Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILAs by a new radio receptor assay. J Clin Endocrinol Metab 38:931-934, 1974
Gorden P, Hendricks CM, Kahn CR, Megyesi K, Roth J: Hypoglycemia associated with non-islet-cell tumor and insulin-like growth factors. N Engl J Med 305:1452-1455, 1981
DaughadayWH, Trivedi B, Kapadia M: Measurement of insulin-like growth factor II by a specific radio receptor assay in serum of normal individuals, patients with abnormal growth hormone secretion, and patients with tumor-associated hypoglycemia. J Clin Endocrinol Metab 53:289-294, 1981
Zapf J, Walter H, Froesch ER: Radio immunological determination of insulin like growth factors I and II in normal subjects and in patients with growth disorders and extra pancreatic tumor hypoglycemia. J Clin Invest 68:1321-1330, 1981
Kahn CR: The riddle of tumor hypoglycemia revisited. Clin Endocrinol Metab 9:335-360, 1980
Zapf J: Role of insulin-like growth factor II and IGF binding proteins in extra pancreatic tumor hypoglycemia. Horm Res 42:20-26, 1994
Bartholomew LG, Schutt AJ: Systemic syndromes associated with neoplastic disease including cancer of the colon. Cancer 28:170-174, 1971
Tranquada RE, Bender AB, Biegelman PM: Hypoglycemia associated with carcinoma of the cecum and syndrome of testicular feminization. N Engl J Med 266:1302-1306, 1962
Whang R, Boyden GM, Herring EB, Seltzer HS: Chronic ulcerative colitis, colonic adenocarcinoma and hypoglycemia. Dig Dis 16:45-50
Montgomery JA, Berne CJ: Gastrointestinal tract neoplasms with dependent hypoglycemia. Am J Surg 127:737-739, 1974
Joffe B, Kew M, Beaton G, Kusman B, Seftel H: Serum somatomedin and insulin levels in tumor hypoglycemia. J Endocrinol Invest 1:269-271, 1978
Skrabanek P, Powell D: Ectopic insulin and Occam's razor: reappraisal of the riddle of tumour hypoglycaemia. Clin Endocrinol (Oxf) 9:141-154, 1978
Hyodo T, Megyesi K, Kahn CR, McLean JP, Friesen HG: Adrenocortical carcinoma and hypoglycemia: evidence for production of nonsuppressible insulin-like activity by the tumor. J Clin Endocrinol Metab 44:1175-1184, 1977
Daughaday WH, Emanuele M, Brooks MH, Barbato AL, Kapadia M, Rotwein P: Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. N Engl J Med 319:1434-1440, 1988
Haselbacher GK, Irminger JC, Zapf J, Ziegler WH, Humbel RE: Insulin-like growth factor II in human adrenal pheochromocytomas andWilms tumors: expression at the mRNA and protein level. Proc Natl Acad Sci USA 84:1104-1106, 1987
Roith DL: Insulin-like growth factors. N Engl J Med 336:633-640, 1997
Baxter RC: Insulin-like growth factor binding proteins as glucoregulators. Metabolism 40(suppl 4):12-17, 1995
Rinderknecht E, Humbel RE: The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem 253:2769-2776, 1978
Rinderknecht E, Humbel RE: Primary structure of human insulinlike growth factor II. FEBS Lett 89:283-286, 1978
Zapf J, Futo E, Peter M, Froesch ER: Can “big” insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia? J Clin Invest 90:2574-2584, 1992
Widmer U, Zapf J, Froesch ER: Is extrapancreatic tumor hypoglycemia associated with elevated levels of insulin-like growth factor II? J Clin Endocrinol Metab 55:833-839, 1982
Unger RH: The riddle of tumor hypoglycemia. Am J Med 40:425-330, 1966
Hardouin S, Gourmelen M, Noguiez P, Seurin D, Roghani M, Le Bouc Y, Povoa G, Merimee TJ, Hossenlopp P, Binoux M: Molecular forms of serum insulin-like growth factor (IGF)-binding proteins in man: relationships with growth hormone and IGFs and physiological significance. J Clin Endocrinol Metab 69:1291-1301, 1989
Baxter RC, Daughaday WH: Impaired formation of the ternary insulin-like growth factor-binding protein complex in patients with hypoglycemia due to nonislet cell tumors. J Clin Endocrinol Metab 73:696-702, 1991
Daughaday WH, Kapadia M: Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors. Proc Natl Acad Sci USA 86:6778-6782, 1989
Shapiro ET, Bell GI, Polonsky KS, Rubenstein AH, Kew MC, Tager HS: Tumor hypoglycemia: relationship to high molecular weight insulin-like growth factor-II. J Clin Invest 85:1672-1679, 1990
Baxter RC, Holman SR, Corbould A, Stranks S, Ho PJ, Braund W: Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in nonislet cell tumor hypoglycemia. J Clin Endocrinol Metab 80:2700-2708, 1995
Rose MG, Tallini G, Pollak J, Murren J: Malignant hypoglycemia associated with a large mesenchymal tumor: case report and review of the literature. Cancer J Sci Am 5:48-51, 1999
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Ko, A.H., Bergsland, E.K. & Lee, G.A. CASE REPORT: Tumor-Associated Hypoglycemia from Metastatic Colorectal Adenocarcinoma: Case Report and Review of the Literature. Dig Dis Sci 48, 192–196 (2003). https://doi.org/10.1023/A:1021836806316
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DOI: https://doi.org/10.1023/A:1021836806316