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Validation of a New Method of Measuring Esophageal Acid Exposure: Comparison with 24-Hour pH Monitoring

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Abstract

Recently, we developed a disposable acid exposure sensor whose in vitro response to acid below pH 4 is linearly determined by the duration of exposure and the degree of acidity. The aim of the present study was to compare the SR to simultaneous esophageal pH and duodenogastroesophageal reflux (DGER) monitoring (Bilitec) in patients investigated for presumed gastroesophageal reflux disease (GERD). Twenty-six patients (16 men, mean age 46 ± 2 years) with symptoms suggestive of GERD underwent 24-hr ambulatory pH monitoring and SR monitoring at 5 cm proximal to the LES. DGER monitoring was performed in 21 patients. Exposure of the esophagus to acid and to DGER were analyzed. These data were compared to SR. A significant correlation was found between the exposure of the distal esophagus to acid and SR (R = 0.85; P < 0.0001). Similarly, the area below a cutoff pH 4 was significantly correlated to SR (r = 0.81; P < 0.0001). SR was not correlated to DGER (r = 0.16; NS). At a cutoff of 50, the sensitivity and specificity of SR to predict esophageal acid exposure >5% of time were 91% and 93%, respectively conclusion, the response of the acid exposure sensor is strongly correlated with the results of simultaneous esophageal pH monitoring. The sensor seems able to reliably predict pathological esophageal acid exposure. These findings warrant larger studies of the clinical potential of the acid exposure sensor in the diagnosis and quantification of GERD.

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Authors and Affiliations

  1. Center for Gastroenterological Research, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium

    J. Tack, G. Vantrappen, D. Sifrim & J. Janssens

  2. Department of Internal Medicine, University Hospital Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium

    J. Tack

  3. Interuniversity Micro Electronics Centre, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium

    G. Huyberechts & R. Van Overstraeten

Authors
  1. J. Tack
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  2. G. Vantrappen
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  3. G. Huyberechts
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  4. D. Sifrim
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  5. J. Janssens
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  6. R. Van Overstraeten
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Tack, J., Vantrappen, G., Huyberechts, G. et al. Validation of a New Method of Measuring Esophageal Acid Exposure: Comparison with 24-Hour pH Monitoring. Dig Dis Sci 48, 16–21 (2003). https://doi.org/10.1023/A:1021717911342

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  • DOI: https://doi.org/10.1023/A:1021717911342

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