Abstract
Brain energy metabolism associated with different functional states and different types of human and animal activity is accompanied by dynamic changes in the degree of linkage between glycolysis and oxidative phosphorylation in different cell compartments [20–23, 25]. These processes are reflected in the redox state of brain tissue [27] and can be recorded potentiometrically as changes in the redox state potential (E) of brain tissue [24]. Studies of E in the cortex of rabbits using implanted platinum electrodes showed that during the acquisition of a conditioned defensive reflex using a combination of a light and a mild electric shock to one of the rabbit's ears, cortical E showed oscillations with periods of several seconds after 5–15 combinations. This number of combinations started to be accompanied by generalized changes in E in the cortex, which, at 20–100 combinations, could be either an increase or a decrease in E. As the number of combinations increased, increases in E were gradually replaced by decreases. By 200–400 combinations, oscillations in E disappeared and the episodes of decreased E accompanying combinations acquired a stable local character. These results suggest that there is a change in the balance of the major sources of brain tissue energy supply during the formation and stabilization of a conditioned defensive reflex: at the initial stages of acquisition of the conditioned reflex a number of cortical points have an energy supply dominated by tissue respiration, while the main energy source for brain function during performance of the acquired conditioned defensive reflex is glycolysis.
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REFERENCES
T. S. Naumova, Electrophysiological Analysis of the Formation of Conditioned Reflexes [in Russian], Meditsina, Moscow (1968).
R. B. Shvets, “Electrochemical (EC) changes and alterations in the constant potential during acquisition of a conditioned reflex,” in: Proceedings of the 25th Congress on Questions of Higher Nervous Activity [in Russian], Gor'kii (1972), Vol. 1, p. 266.
T. B. Shvets, “Reflection of the activity of different parts of the cerebral cortex associated with orientational reactions and the formation of a conditioned defensive reflex in bioelectrochemical processes and changes in the constant potential in rabbits,” in: Proceedings of the 5th All-Union Conference on Neurocybernetics [in Russian], Rostov-on-Don (1973), p. 343.
T. B. Shvets, “Electrographic studies of vital metabolism in the brain during acquisition of a conditioned defensive reflex,” in: Memory and Trace Processes [in Russian], Nauka, Pushchino-na-Oke (1974), p. 98.
T. B. Shvets, “Reflection of the process of formation of memories in trace changes of the bioelectrochemical potential,” in: Memory and Trace Processes [in Russian], Nauka, Pushchino-na-Oke (1974), p. 293.
T. B. Shvets, “Displacements of areas of peak changes in the electrochemical potential of the brain surface during extinction and restoration of a conditioned reflex,” Zh. Vyssh. Nerv. Deyat., 26, No. 4, 863 (1976).
T. B. Shvets-Ténéta-Gurii, “Slow electrical and metabolic process in the cerebral cortex accompanying orientational reactions and the formation of a conditioned defensive reflex,” in Proceedings of the 25th Congress on Questions of Higher Nervous Activity [in Russian], Moscow (1977), Vol. 1, p. 172.
T. B. Shvets-Ténéta-Gurii, “Recording of electrochemical activity in the brain as a method for studying metabolic changes linked with higher nervous activity,” Zh. Vyssh. Nerv. Deyat., 29, No. 4, 879 (1979).
T. B. Shvets-Ténéta-Gurii, “Changes in the constant potential and alterations in the bioelectrochemical potential of the brain in conditioned and orientational reflexes in rabbits,” Zh. Vyssh. Nerv. Deyat., 29, No. 5, 915 (1979).
T. B. Shvets-Ténéta-Gurii, “Two stages in the metabolic processes of the rabbit brain accompanying the formation of a conditioned defensive reflex,” in: Regulatory Mechanisms of Memory [in Russian], Nauka, Leningrad (1980), p. 26.
T. B. Shvets-Ténéta-Gurii, Bioelectrochemical Activity of the Brain [in Russian], Nauka, Moscow (1980).
T. B. Shvets-Ténéta-Gurii, “Slow bioelectrochemical activity (BECA) and changes in the constant brain potential in an orientational reaction and a conditioned defensive reflex,” in: Proceedings of the 27th Congress on Questions of Higher Nervous Activity [in Russian], Leningrad (1984), p. 316.
T. B. Shvets-Ténéta-Gurii, Bioelectrochemical Activity of the Brain during Learning [in Russian], Nauka, Moscow (1986).
T. B. Shvets-Ténéta-Gurii, “The motor cortex dominant, the defensive dominant, and a defensive conditioned reflex in the light of studies of changes in the constant potential and slow changes in the electrochemical activity of the cerebral cortex,” in: The Dominant and Conditioned Reflexes [in Russian], Nauka, Moscow (1987), p. 117.
T. B. Shvets-Ténéta-Gurii, V. N. Mats, and O. B. Kovchegova, “Rhythms of slow sleep and waking in oscillations of the redox state potential of the cerebral cortex,” Byull. Éksperim. Biol. Med., 108, No. 9, 259 (1989).
T. B. Shvets-Ténéta-Gurii, “The process of formation and stabilization of a conditioned defensive reflex is accompanied by a shift in the energy source of the cerebral cortex during combinations,” in: Proceedings of the XVII Congress of Russian Physiologists [in Russian], Leningrad (1988), p. 34.
T. B. Shvets-Ténéta-Gurii, “Potential of the redox state-potential of the cerebral cortex during hypnosis (immobilization stress) in rabbits,” Dokl. Akad. Nauk SSSR, 315, No. 4, 1014 (1989).
T. B. Shvets-Ténéta-Gurii,, M. R. Novikova, I. N. Tveritskaya, and I. N. Khonicheva, “Is the electrical activity of the brain always electrical? (Factors forming the potential at a metal electrode in direct contact with the brain),” Zh. Vyssh. Nerv. Deyat., 43, No. 1, 182 (1993).
M. Fillenz, “Physiological release of excitatory amino acids,” Behav. Brain Res., 71, No. 1, 51 (1995).
P. T. Fox, “Functional brain mapping with positron emission tomography,” Semin, Neurol., 9, No. 4, 323 (1989).
P. T. Fox, M. E. Raichle, M. A. Mintun, and C. Dence, “Nonoxidative glucose consumption during focal physiologic neural activity,” Science, 241, 462 (1988).
L. Pellerin and P. J. Magistretti, “Glutamate uptake into astrocytes stimulates aerobic glycolysis: A Mechanism coupling neuronal activity to glucose utilization,” Proc. Natl. Acad. Sci. USA, 91, 10625 (1994).
J. Prichard, D. Rothman, E. Novotny, et al., “Lactate rise detected by 1H NMR in human visual cortex during physiological stimulation,” Proc. Natl. Acad. Sci. USA, 88, 5829 (1991).
A. Puppi and M. Dely, “Tissue redox-state potential (E) as regulator of the physiological processes,” Acta Biol. Hung., 34, No. 2, 323 (1983).
A. Schur, G. G. Miller, R. S. Payne, and B. M. Rigor, “An increase in lactate output by brain tissue serves to meet the energy needs of glutamate activated neurons,” J. Neurosci., 19, No. 1, 34 (1999).
T. B. Shvets-Teneta-Gurii, A. G. Dubinin, and E. L. Ivanova-Anninskaya, “Brain electrochemical potential alterations monitored by platinum electrodes in behaving animals,” Electro-and Magnetobiol., 15, No. 1, 1 (1996).
B. K. Siesjo, Brain Energy Metabolism, J. Wiley and Sons, Chichester, New York, Brisbane, Toronto (1978).
I. A. Silver and M. Ereskinska, “Ion homeostasis in brain cells: different responses to energy limitation between cultured neurons and glial cells,” Neuroscience, 78, No. 2, 589 (1997).
R. A. Swanson, M. M. Morton, S. M. Sagar, and F. R. Sharp, “Sensory stimulation induces local cerebral glycogenolysis. Demonstration by autoradiography,” Neuroscience, 51, No. 2, 451 (1992).
M. Tsacopoulos, C. L. Poitry-Yamata, and S. Poitry, “The nutritive function of glia is regulated by signals released by neurones,” Glia, 21, No. 1, 84 (1997).
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Shvets-Ténéta-Gurii, T.B., Troshin, G.I., Mats, V.N. et al. Dynamics of Local Changes and Oscillations in Energy Metabolism in the Rabbit Cerebral Cortex during the Formation of a Conditioned Defensive Reflex. Neurosci Behav Physiol 33, 99–106 (2003). https://doi.org/10.1023/A:1021705427273
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DOI: https://doi.org/10.1023/A:1021705427273