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Myosin Light Chain Kinase Inhibitors Induce Retraction of Mature Oligodendrocyte Processes

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Abstract

Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligodendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.

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Authors and Affiliations

  1. IIB Fundación Campomar, IIB FCEyN, University of Buenos Aires and IIBBA-CONICET, Buenos Aires, Argentina

    María G. Thomas, Tomás A. Santa Coloma & Graciela L. Boccaccio

  2. Instituto de Investigaciones Neurológicas “Dr. Raúl Carrea,” FLENI, Buenos Aires, Argentina

    María G. Thomas & Jorge Correale

Authors
  1. María G. Thomas
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  2. Tomás A. Santa Coloma
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  3. Jorge Correale
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  4. Graciela L. Boccaccio
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Thomas, M.G., Santa Coloma, T.A., Correale, J. et al. Myosin Light Chain Kinase Inhibitors Induce Retraction of Mature Oligodendrocyte Processes. Neurochem Res 27, 1305–1312 (2002). https://doi.org/10.1023/A:1021615530960

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