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Letter to the Editor: Assignment of backbone 1H, 13C, and 15N resonances of the SH2 domain of human Grb14

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Abstract

The 1H, 13C, and 15N backbone resonance assignments have been made for the Src homology 2 (SH2) domain of the human molecular adapter protein Grb14. The assignments, along with the majority of the non-aromatic side-chain 1H and 13C resonances are reported. The SH2 domain has been complexed with a phosphotyrosine-containing peptide (pY766) corresponding to the putative binding site in the fibroblast growth factor receptor (FGFR1). Chemical shift changes upon binding are also reported.

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Authors and Affiliations

  1. Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT, 05405, U.S.A

    Paul J. Scharf & Barbara A. Lyons

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  1. Paul J. Scharf
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  2. Barbara A. Lyons
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Correspondence to Barbara A. Lyons.

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Scharf, P.J., Lyons, B.A. Letter to the Editor: Assignment of backbone 1H, 13C, and 15N resonances of the SH2 domain of human Grb14. J Biomol NMR 24, 275–276 (2002). https://doi.org/10.1023/A:1021612725752

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  • DOI: https://doi.org/10.1023/A:1021612725752

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