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Possible Involvement of Neurokinin Receptors in CNS and Neuromuscular Synapse in the Realization of the Effects of CAPAH and Substance P

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Abstract

Nootropic non-anticholinesterase organophosphorus preparation CAPAH and substance P produced similar and dose-dependent effects on the amplitude and temporal parameters of miniature endplate potentials in mammalian neuromuscular synapse. Neurokinin receptor antagonist Win-51.708 abolished the effects of these agents. In behavioral experiments substance P moderated the mnemotropic and antidepressant effects of CAPAH. It was assumed that neurokinin receptors are the targets of CAPAH and substance P in CNS and neuromuscular synapse.

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Authors and Affiliations

  1. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan State Medical University, Kazan

    I. I. Semina

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  1. I. I. Semina
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  2. E. A. Bukharaeva
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  3. E. V. Shilovskaya
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  4. A. Z. Baichurina
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  5. R. S. Garaev
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Semina, I.I., Bukharaeva, E.A., Shilovskaya, E.V. et al. Possible Involvement of Neurokinin Receptors in CNS and Neuromuscular Synapse in the Realization of the Effects of CAPAH and Substance P. Bulletin of Experimental Biology and Medicine 134, 267–270 (2002). https://doi.org/10.1023/A:1021511719307

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