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Mechanisms of Changes in the Hemoglobin Profile during Acute Adaptation to Extreme Conditions

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Abstract

We studied changes in rat hemoglobin isoforms during acute adaptation to various hypoxic conditions. Erythrocytes were heterogeneous in the content of various hemoglobin isoforms. Changes in the hemoglobin profile during hypoxia are related to variations in the ratio between populations of erythrocytes differing in the content of individual hemoglobin isoforms.

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REFERENCES

  1. M. V. Borisyuk, Usp. Fiziol. Nauk, 14,No. 1, 85–101 (1983).

    Google Scholar 

  2. Hypoxia. Adaptation, Pathogenesis, and Clinics [in Russian], St. Petersburg (2000).

  3. G. Maurer, Disk Electrophoresis. Theory and Practice of Electrophoresis in Polyacrylamide Gel [in Russian], Moscow (1971).

  4. A. D. Pavlov and E. F. Morshchakova, Regulation of Erythropoiesis [in Russian], Moscow (1987).

  5. N. F. Starodub and V. I. Nazarenko, Heterogeneous System of Hemoglobin. Structure, Properties, Synthesis, and Biological Role [in Russian], Kiev (1987).

  6. N. F. Starodub, V. P. Artyukhov, A. N. Gritsak, and Yu. L. Radavskii, Ukr. Biokhim. Zh., 51,No. 2, 117–129 (1979).

    Google Scholar 

  7. H. Bard, J. C. Fourton, C. Gagnon, and G. Gagnon, J. Pediatr., 124,No. 6, 941–943 (1994).

    Google Scholar 

  8. J. E. Barker, Blood, 56, 495–500 (1980).

    Google Scholar 

  9. J. E. Barker, J. E. Pierce, and A. W. Nienhuis, Cellular and Molecular Regulation of Hemoglobin Switching, Eds. G. Stamatoyannopoulos and A. W. Nienhuis, New York (1979), pp. 179–192.

  10. E. Kleihauer, T. E. Tang, and K. Betke, Acta Haematol., 38, 264–272 (1967).

    Google Scholar 

  11. T. Umemura, A. Al-Khatti, T. Papayannopoulou, and G. Stamatoyannopoulos, Proc. Natl. Acad. Sci. USA, 23, 9278–9282 (1988).

    Google Scholar 

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Chereshnev, V.A., Sumin, M.N., Rezaikin, A.V. et al. Mechanisms of Changes in the Hemoglobin Profile during Acute Adaptation to Extreme Conditions. Bulletin of Experimental Biology and Medicine 134, 223–225 (2002). https://doi.org/10.1023/A:1021434929785

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  • DOI: https://doi.org/10.1023/A:1021434929785

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