Behavior Genetics

, Volume 28, Issue 3, pp 159–163 | Cite as

Validation of a Telephone Zygosity Questionnaire in Twins of Known Zygosity

  • Hilde Peeters
  • Sofie Van Gestel
  • Robert Vlietinck
  • Catherine Derom
  • Robert Derom
Article

Abstract

The aim of this study was to validate a zygosity questionnaire that can be administered over the telephone. Mothers of same-sexed twins of known zygosity and chorionicity between 2 and 31 years of age were interviewed on a nine-item questionnaire. From the answers one unweighted and four weighted indices were computed. As single questions, the mother's opinion and the “two peas in a pod” question differentiated best between monozygotic and dizygotic twins. One independent well-trained observer assessed the zygosity based on the questionnaire and made the correct diagnosis in 96% of the cases. A weighted index of eight similarity questions yielded an accuracy of 98%. This study shows that the zygosity of same-sexed twins more than 2 years old and without gross physical malformation can reliably be determined by a telephone questionnaire with a high accuracy.

Twins similarity zygosity telephone questionnaire 

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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Hilde Peeters
    • 1
  • Sofie Van Gestel
    • 1
  • Robert Vlietinck
    • 1
  • Catherine Derom
    • 1
  • Robert Derom
    • 1
  1. 1.Center for Human GeneticsKatholieke Universiteit Leuven, Herestraat 49LeuvenBelgium

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