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Preparation, spectral characterization, in vitro antitumor and thermal studies of new platinum(IV) and palladium(II) thiohydrazone complexes

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PtIV and PdII complexes [Pt(L)2Cl2] and [Pd(HL)Cl2] [HL = salicyclaldehyde morpholine N-thiohydrazone (HL1), benzaldehyde morpholine N-thiohydrazone (HL2), acetophenone morpholine N-thiohydrazone (HL3), p-methylacetophenone morpholine N-thiohydrazone (HL4), cinnamaldehyde morpholine N-thiohydrazone (HL5), cyclohexanone morpholine N-thiohydrazone (HL6), benzaldehyde aniline N-thiohydrazone (HL7), benzaldehyde N-(methyl, cyclohexyl)-thiohydrazone (HL8) and benzaldehyde N-(ethyl, cyclohexyl)-thiohydrazone (HL9)] were prepared in MeOH and characterized by elemental analysis, i.r., electronic, 1H-n.m.r. and 13C-n.m.r. spectral data. For some of the complexes cyclic voltammetric and thermal studies were carried out. The in vitro antitumor activity of some complexes was measured.

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  1. Department of Chemistry, University of Delhi, Delhi, 110007, India

    Navneet Manav & Narender Kumar Kaushik

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  1. Navneet Manav
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  2. Narender Kumar Kaushik
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Manav, N., Kaushik, N.K. Preparation, spectral characterization, in vitro antitumor and thermal studies of new platinum(IV) and palladium(II) thiohydrazone complexes. Transition Metal Chemistry 27, 849–855 (2002). https://doi.org/10.1023/A:1021390024486

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