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Retinoic acid modulates the level of nerve growth factor gene expression and proliferation of cultured human keratinocytes

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Abstract

Retinoic acid (RA) inhibited proliferation of cultured human keratinocytes. Southern blot analysis at 24 h showed that RA inhibited nerve growth factor (NGF) mRNA synthesis in a dose-dependent manner. However, RA stimulated the production of NGF protein up to 187% of control after 96 h and the treatment of cells with RA did not enhance apoptosis, either in the presence of low or high concentration of Ca2+, when compared to the control with DMSO.

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Authors and Affiliations

  1. College of Life and Environmental Sciences, Korea University, Seoul, 136-701, Korea

    Jin-Woo Lee, Yong Kwon Lee, Bok-Hwan Chun, Won-Gi Bang & Nahmhyun Chung

  2. East-West Medical Research Institute, College of Medicine, Kyung Hee University Medical Center, Seoul, 136-701, Korea

    Jin-Woo Lee

  3. Department of Dermatology, College of Medicine, Kyung Hee University Medical Center, Seoul, 136-701, Korea

    Mu-Hyoung Lee & Young-Woo Jin

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  1. Jin-Woo Lee
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  2. Yong Kwon Lee
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  3. Bok-Hwan Chun
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Lee, JW., Lee, Y.K., Chun, BH. et al. Retinoic acid modulates the level of nerve growth factor gene expression and proliferation of cultured human keratinocytes. Biotechnology Letters 24, 2035–2040 (2002). https://doi.org/10.1023/A:1021363203406

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  • DOI: https://doi.org/10.1023/A:1021363203406

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