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The cadherin superfamily database

Journal of Structural and Functional Genomics volume 2, pages 135–143 (2002)Cite this article

Abstract

The cadherin superfamily is a large protein family with diverse structures and functions. Because of this diversity and the growing biological interest in cell adhesion and signaling processes, in which many members of the cadherin superfamily play a crucial role, it is becoming increasingly important to develop tools to manage, distribute and analyze sequences in this protein family. Current profile and motif databases classify protein sequences into a broad spectrum of protein superfamilies, however to provide a more specific functional annotation, the next step should include classification of subfamilies of these protein superfamilies. Here, we present a tool that classified greater than 90% of the proteins belonging to the cadherin superfamily found in the SWISS PROT database. Therefore, for most members of the cadherin superfamily, this tool can assist in adding more specific functional annotations than can be achieved with current profile and motif databases. Finally, the classification tool and the results of our analysis were integrated into a web-accessible database (http://calcium.uhnres. utoronto.ca/cadherin).

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Affiliations

  1. Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    Kevin Truong & Mitsuhiko Ikura

Authors
  1. Kevin Truong
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  2. Mitsuhiko Ikura
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Truong, K., Ikura, M. The cadherin superfamily database. J Struct Func Genom 2, 135–143 (2002). https://doi.org/10.1023/A:1021352716284

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  • DOI: https://doi.org/10.1023/A:1021352716284

Keywords

  • Crucial Role
  • Signaling Process
  • Cell Adhesion
  • Protein Sequence
  • Protein Family