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Cancer and Metastasis Reviews

, Volume 21, Issue 3–4, pp 291–295 | Cite as

Zinc in Cancer Prevention

  • Ananda S. Prasad
  • Omer Kucuk
Article

Abstract

Epidemiologic studies suggest that zinc deficiency may be associated with increased risk of cancer. However, few studies have been conducted with zinc supplementation in animals and humans. Most previous intervention studies have used zinc in combination with several other micronutrients, which make them difficult to interpret. Zinc supplementation is associated with decreased oxidative stress and improved immune function, which may be among the possible mechanisms for its cancer preventive activity. Preclinical and clinical studies need to investigate modulation of genetic and epigenetic pathways of carcinogenesis by zinc.

zinc cancer prevention immune function nutrition head and neck cancer 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Ananda S. Prasad
    • 1
  • Omer Kucuk
    • 2
  1. 1.Department of Medicine (Division of Hematology–Oncology); Department of Molecular Medicine and Genetics, Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitUSA
  2. 2.Department of Medicine (Division of Hematology–Oncology), Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitUSA

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