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Plasma Content of Soluble Fas Antigen in Patients with Adrenal Tumors and Tumor-Like Pathologies

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Abstract

We compared plasma content of soluble Fas antigen (sFas) in 59 patients with tumors and tumor-like pathologies of the adrenal cortex and medulla and 60 healthy donors (control). The incidence and content of sFas in the plasma from patients with adrenal tumors was significantly higher than in healthy donors. A direct correlation was found between sFas content and patient's age. The maximum sFas concentrations were found in patients with pheochromocytoma and aldosterone-producing adenoma. In patients with adrenocortical cancer plasma content of sFas was lower than in patients with tumors of other morphological types. Plasma sFas content in patients with adrenocortical cancer directly correlated with the size of tumors. Our results suggest that sFas plays a role in the pathogenesis of primary adrenal tumors.

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Authors and Affiliations

  1. N. N. Blokhin Russian Oncological Center, Russian Academy of Medical Sciences, Russia

    N. E. Kushlinskii, T. A. Britvin, G. A. Polyakova, S. G. Abbasova, A. A. Baronini, R. S. Tishenina, G. S. Molchanova, V. Yu. Sel'chuk, D. A. Pirogov, O. P. Bogatyrev, V. M. Lipkin & A. P. Kalinin

  2. M. F. Vladimirskii Moscow Regional Research-and-Clinical Institute, Russia

    N. E. Kushlinskii, T. A. Britvin, G. A. Polyakova, S. G. Abbasova, A. A. Baronini, R. S. Tishenina, G. S. Molchanova, V. Yu. Sel'chuk, D. A. Pirogov, O. P. Bogatyrev, V. M. Lipkin & A. P. Kalinin

  3. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow

    N. E. Kushlinskii, T. A. Britvin, G. A. Polyakova, S. G. Abbasova, A. A. Baronini, R. S. Tishenina, G. S. Molchanova, V. Yu. Sel'chuk, D. A. Pirogov, O. P. Bogatyrev, V. M. Lipkin & A. P. Kalinin

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  1. N. E. Kushlinskii
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  2. T. A. Britvin
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  3. G. A. Polyakova
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  4. S. G. Abbasova
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  5. A. A. Baronini
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  6. R. S. Tishenina
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  7. G. S. Molchanova
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  8. V. Yu. Sel'chuk
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  9. D. A. Pirogov
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  10. O. P. Bogatyrev
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  11. V. M. Lipkin
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  12. A. P. Kalinin
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Kushlinskii, N.E., Britvin, T.A., Polyakova, G.A. et al. Plasma Content of Soluble Fas Antigen in Patients with Adrenal Tumors and Tumor-Like Pathologies. Bulletin of Experimental Biology and Medicine 134, 171–174 (2002). https://doi.org/10.1023/A:1021196517353

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