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Pine Resin and Biopin Ointment: Effects of Water-Soluble Fractions on Cytokine Production by Peripheral Blood Neutrophils

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Abstract

We studied the effects of water-soluble fractions of pine resin and Biopin-10 and Biopin-20 ointments used for the therapy of burns, wounds, and purulent and inflammatory diseases on spontaneous and induced synthesis of tumor necrosis factor and interleukins 1, 2, and 8 by human peripheral blood neutrophils in vitro. These preparations contain various bioactive substances producing opposite and dose-dependent immunomodulatory effects. Our results indicate that the composition and doses of preparations should be selected to achieve the maximum therapeutic effect.

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REFERENCES

  1. B. A. Paramonov and G. Sh. Mchedlidze, Therapy of Burns, Wounds, and Trophic Ulcers by Ointment Biopin [in Russian], St. Petersbutg (2001).

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Authors and Affiliations

  1. Institute of High-Purity Biological Preparations, St. Petersburg-Technology, St. Petersburg

    A. S. Simbirtsev, V. G. Konusova, G. Sh. Mchedlidze, B. A. Paramonov & V. Yu. Chebotarev

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  1. A. S. Simbirtsev
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  2. V. G. Konusova
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  3. G. Sh. Mchedlidze
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  4. B. A. Paramonov
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  5. V. Yu. Chebotarev
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Simbirtsev, A.S., Konusova, V.G., Mchedlidze, G.S. et al. Pine Resin and Biopin Ointment: Effects of Water-Soluble Fractions on Cytokine Production by Peripheral Blood Neutrophils. Bulletin of Experimental Biology and Medicine 134, 151–155 (2002). https://doi.org/10.1023/A:1021184214627

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  • DOI: https://doi.org/10.1023/A:1021184214627

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