REFERENCES
Morton H, Hegh V, Clunie GJA: Immunosuppression detected in pregnant mice by rosette inhibition test. Nature 1974;249:459–460
Morton H, Hegh V, Clunie GJA: Studies of the rosette inhibition test in pregnant mice: evidence of immunosuppression? Proc R Soc B 1976;193:413–419
Cavanagh AC, Morton H: Early pregnancy factor: purification to homogeneity from human platelets and identification as chaperonin 10. Eur J Biochem 1994;222:551–560
Cavanagh AC, Morton H, Athanasas-Platsis S, Quinn KA, Rolfe BE: Identification of a putative inhibitor of early pregnancy factor in mice. J Reprod Fert 1991;91:239–248
Cavanagh AC, Rolfe BE, Athanasas-Platsis S, Quinn KA, Morton: Relationship between early pregnancy factor, mouse embryo conditioned medium and platelet activating factor. J Reprod Fert 1991;93:355–365
Morton H, Rolfe BE, Cavanagh AC: Early pregnancy factor. Semin Reprod Endocrinol 1992;10:72–82
Quinn KA, Cavanagh AC, Hillyard NC, McKay DA, Morton H: Early pregnancy factor (EPF) in liver regeneration after partial hepatectomy in rats: its relationship to chaperonin 10. Hepatology 1994;20:1294–1302
Hartmann DJ, Hoogenraad NJ, Condron R, Hoj PB: Identification of a mammalian 10-kDa heat shock protein, a mitochondrial chaperonin 10 homologue essential for assisted folding of trimeric ornithine transcarbamoylase in vitro. Proc Natl Acad Sci USA 1992;89:3394–3398
Summers KM, Murphy RM, Webb GC, Peters GB, Cassady Al, Morton H, Cavanagh AC: The human early pregnancy factor/chaperonin 10 gene family. Biochem Mol Med 1996;58:52–58
Ellis RJ, van der Vies SM: Molecular chaperones. Annu Rev Biochem 1991;60:321–347
Lindquist S, Craig EA: The heat-shock proteins. Annu Rev Genet 1988;22:631–677
Zeilstra-Ryalls J, Fayet O, Georgopoulos C: The universally conserved groE (hsp60) chaperonins. Annu Rev Microbiol 1991;45:301–325
Athanasas S, Quinn KA, Wong TY, Rolfe BE, Cavanagh AC, Morton H: Passive immunization of pregnant mice against early pregnancy factor (EPF) causes loss of embryonic viability. J Reprod Fert 1989;87:495–502
Quinn KA, Athanasas-Platsis S, Wong T-Y, Rolfe BE, Cavanagh AC, Morton H: Monoclonal antibodies to early pregnancy factor perturb tumour cell growth. Clin Exp Immunol 1990;80:100–108
Athanasas-Platsis S, Morton H, Dunglison GF, Kaye PL: Antibodies to early pregnancy factor retard embryonic development in mice in vivo. J Reprod Fert 1991;92:443–451
Quinn KA, Morton H: Effect of anti-EPF monoclonal antibodies on the in vivo growth of transplanted murine tumours. Cancer Immunol Immunother 1992:34:265–271
Athanasas-Platsis S: Early Pregnancy Factor: A Study of its Immunomodulatory and Growth Regulatory Properties During Pregnancy, PhD thesis. Brisbane: University of Queensland, 1993
Cavanagh AC, Morton H: Chaperonin 10. International Patent Application PCT/AU94/00740, 1995
Morton H, Cavanagh AC: Antagonists to chaperonin 10. International Patent Application PCT/AU94/00742, 1995
Love SG, Engelbretsen DR, Gamham B, Cavanagh AC, Morton H, Chemusevich I, Standing K, Alewood PF: Observation of protein heptamer formation for chemically ligated early pregnancy factor. Proceedings of NATOARW on New Methods for the Study of Molecular Aggregates. NATO ASI, Kluwer, 1997 (in press)
Kaye PL, Corcoran CM, Pantaleon M, Cavanagh AC, Morton H: Early pregnancy factor/chaperonin 10 in preimplantation mouse embryos. J Reprod Fert 1996; Abstr Ser 17:p6, abstr 11
Clarke FM, Orozco C, Perkins AV, Cock I, Tonissen KF, Robins AJ, Wells JRE: Identification of molecules involved in the “early pregnancy factor” phenomenon. J Reprod Fert 1991;93:526–539
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cavanagh, A.C. An Update on the Identity of Early Pregnancy Factor and Its Role in Early Pregnancy. J Assist Reprod Genet 14, 492–495 (1997). https://doi.org/10.1023/A:1021162923504
Issue Date:
DOI: https://doi.org/10.1023/A:1021162923504