Abstract
Polymorphism of highly polymorphic triplet repeats CTG of the 3"-untranslated region of the myotonin protein kinase gene and CAG of the genes associated with dentatorubral-pallidoluysian atrophy (DRPLA, or Hew River syndrome) and spinocerebellar ataxia type 1 (SCA1) was analyzed in several ethnic populations of Russia. A difference in allele spectra of the three genes was demonstrated for populations differing in ethnic origin.
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REFERENCES
Brook, J.D., McCurrach, M.E., Harley, H.G., et al., Molecular Basis of Myotonic Dystrophy: Expansion of a Trinucleotide (CTG) Repeat at the 3′ End of a Transcript Encoding a Protein Kinase Family Member, Cell (Cambridge, Mass.), 1992, vol. 68, pp. 799–808.
Caskey, C.T., Pizutty, A., Fu, Y.H., et al., Triplet Repeat Mutation in Human Disease, Science, 1992, vol. 256, pp. 784–789.
Koide, R., Ikeuchi, T., Onodera, O., et al., Unstable Expansion of CAG Repeat in Hereditary Dentatorubral-Pallidoluysian Atrophy (DRPLA), Nat. Genet., 1994, vol. 6, pp. 9–13.
Gusella, J.F. and Mac Donald, M.E., Trinucleotide Instability: A Repeating Theme in Human Inherited Disorders, Annu. Rev. Med., 1996, vol. 47, pp. 201–209.
Popova, S.N., Mikulich, A.I., Slominskii, P.A., et al., Polymorphism of the (CTG)n Repeat of the Myotonin Protein Kinase (DM) Gene in the Belorussian Population: Analysis of the Interethnic Heterogeneity, Genetika (Moscow), 1999, vol. 35, no. 7, pp. 994–997.
Slominsky, P.A., Popova, S.N., Shadrina, M.I., et al., Normal Polymorphism of the (CGT)n Repeat of the Myotonin Protein Kinase (DM) Gene on Chromosome 19q13.3 in East European Populations, Genetika (Moscow), 2000, vol. 36, no. 7, pp. 980–985.
Malysheva, O.V., Ivashchenko, T.E., and Baranov, V.S., Population and Family Studies of the CAG Repeat of the IT-15 Gene, Genetika (Moscow), 2001, vol. 37, no. 3, pp. 402–406.
Gyurus, J.M., Molnar, J., Melegh, B., et al., Trinucleotide Repeat Polymorphism at Five Disease Loci in a Mixed Hungarian Population, Am. J. Med. Genet., 1999, vol. 87, pp. 245–250.
Richards, R.I., Crawford, J., Narahara, K., et al., Dynamic Mutation Loci: Allele Distribution in Different Populations, Ann. Hum. Genet., 1996, vol. 60, pp. 391–400.
Kulemzin, V.M. and Lukina, N.V., Znakom'tes': khanty (Meet Khants), Novosibirsk: Novosibirsk. Knizhn. Izd., 1992.
Miller, S.A., Dykes, D.D., and Polesky, H.F., A Sample Salting-Out Procedure for Extracting DNA from Human Nucleated Cells, Nucleic Acids Res., 1988, vol. 16, p. 1215.
Orr, H.T., Chung, M.Y., Banfi, S., et al., Expansion of an Unstable Trinucleotide CAG Repeat in Spinocerebellar Ataxia Type 1, Nat. Genet., 1993, vol. 4, pp. 221–226.
Nagafuchi, S., Yanagisawa, H., Sato, K., et al., Denta-torubral and Palladoluysian Atrophy: Expansion of an Unstable CAG Trinucleotide on Chromosome 12p, Nat. Genet., 1994, vol. 6, pp. 14–18.
Lewis, P.O. and Zaykin, D., Genetic Data Analysis Software (GDA) Version 1d15, http://lewis.eeb.uconn.edu/lewishome/gda.html.
Weir, B.S., Genetic Data Analysis, Sunderland, Mass.: Sinauer, 1990.
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Popova, S.N., Slominsky, P.A., Galushkin, S.N. et al. Analysis of the Allele Polymorphism of (CTG)nand (CAG)n Triplet Repeats in Loci DM, DRPLA, and SCA1 in Several Populations of Russia. Russian Journal of Genetics 38, 1312–1315 (2002). https://doi.org/10.1023/A:1021159413816
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DOI: https://doi.org/10.1023/A:1021159413816