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Effect of Chronic Administration of Imipramine on 2A-Serotonin Receptor mRNA in Brain Cortex of Rats Predisposed and Resistant to Catalepsy

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Abstract

Rats selected by predisposition to catalepsy showed decreased level of 2A-serotonin receptor mRNA in the frontal cortex in comparison with Wistar rats (p<0.05). Chronic administration of tricyclic antidepressant imipramine hydrochloride 2-fold increased the content of receptor mRNA in genetically cataleptic rats (p<0.001) and did not change this parameter in Wistar rats. These results prompted us to revise current notion on the mechanisms of chronic effect of imipramine on 2A-serotonin receptors.

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REFERENCES

  1. N. N. Barykina, I. L. Chepkasov, T. A. Alekhina, and V. G. Kolpakov, Genetika, 12, 2014–2021 (1983).

    Google Scholar 

  2. A. V. Kulikov, A. V. Maksyutova, E. A. Ivanova, et al., Dokl. RAN, 383, 417–419 (2002).

    Google Scholar 

  3. E. L. Barker and R. D. Blakey, Psychopharmacology. The Fourth Generation of Progress, N. Y. (1985), pp. 321–333.

  4. P. Blier and C. de Montigny, Trends Pharmacol. Sci., 15, 220–226 (1994).

    Google Scholar 

  5. F. Borsini, Pharmacol. Res., 30, 1–11 (1994).

    Google Scholar 

  6. P. W. Burnet, D. Michelson, M. A. Smith, et al., Brain Res., 638, 311–324 (1994).

    Google Scholar 

  7. P. Chomczynski and N. Sacchi, Anal. Biochem., 162, 156–159 (1987).

    Google Scholar 

  8. V. Klimek, J. Zak-Knapik, and M. Mackowiak, J. Psychiatry Neurosci., 19, 63–67 (1994).

    Google Scholar 

  9. E. M. Nikulina, N. K. Popova, V. G. Kolpakov, and T. A. Alekhina, Biogenic Amines, 4, 399–406 (1987).

    Google Scholar 

  10. G. Pineyro and P. Blier, Pharmacol. Rev., 51, 533–591 (1999).

    Google Scholar 

  11. N. K. Popova and A. V. Kulikov, Am. J. Med. Genet., 60, 214–220 (1995).

    Google Scholar 

  12. G. Spurlock, P. Buckland, M. O'Donovan, and P. McGuffin, Neuropharmacology, 33, 433–440 (1994).

    Google Scholar 

  13. M. N. Subhash and S. Jagadeesh, Neurochem. Res., 22, 1095–1099.

  14. P. Willner, Pharmacol. Ther., 45, 425–455 (1990).

    Google Scholar 

  15. P. L. Zamorano, V. B. Mahesh, and D. W. Brann, Neuroendocrinology, 63, 397–407 (1996).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Behaviour Phenogenetics, Laboratory of Evolutionary Genetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    A. V. Kulikov, M. A. Tikhonova, N. N. Barykina, T. A. Alekhina, V. F. Chugui, V. G. Kolpakov & N. K. Popova

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  1. A. V. Kulikov
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  2. M. A. Tikhonova
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  3. N. N. Barykina
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  4. T. A. Alekhina
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  5. V. F. Chugui
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  6. V. G. Kolpakov
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  7. N. K. Popova
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Kulikov, A.V., Tikhonova, M.A., Barykina, N.N. et al. Effect of Chronic Administration of Imipramine on 2A-Serotonin Receptor mRNA in Brain Cortex of Rats Predisposed and Resistant to Catalepsy. Bulletin of Experimental Biology and Medicine 134, 168–170 (2002). https://doi.org/10.1023/A:1021144500515

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