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Relationships between Cerebral Blood Flow Dynamics and Bioelectric Activity of the Human Brain in Experimental Acute Hypoxia

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Abstract

The relationships between the parameters of oxygen content in the body (hemoglobin saturation with oxygen and trancutaneous oxygen tension), central hemodynamics (cardiac output), and cerebral hemodynamics (cerebral blood flow rate) were studied during a hypoxic test (inhalation of an oxygen–nitrogen mixture containing 8% oxygen for 15 min). Special attention was paid to the relationships between the dynamics of cerebral blood flow and cerebral bioelectric activity measured by EEG parameters. It was demonstrated that the trancutaneous oxygen tension decreased to a greater extent than the hemoglobin saturation with oxygen and the cerebral blood flow increased to a greater extent than the cardiac output. The increase in cerebral blood flow and the increase in the indices and power of θ and Δ EEG waves in the course of hypoxia were strongly positively correlated with each other in most subjects. However, if these parameters were considered in the series of subjects, the degree of the increase in the indices and power of θ and Δ waves in different subjects was negatively correlated with the increase in the cerebral blood flow. The results are explained in terms of redistribution of blood flow in the body to provide a better oxygen supply to the brain and optimization of the ratios between the cerebral oxygen consumption and the functional load on the system of oxygen supply.

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Authors and Affiliations

  1. Arktika International Scientific, Research Center, Far East Division, Russian Academy of Sciences, Magadan, Russia

    E. A. Burykh

  2. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 74, St. Petersburg, 194223, Russia

    S. V. Nesterov, S. I. Soroko & N. Yu. Volkov

Authors
  1. E. A. Burykh
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  2. S. V. Nesterov
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  3. S. I. Soroko
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  4. N. Yu. Volkov
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Burykh, E.A., Nesterov, S.V., Soroko, S.I. et al. Relationships between Cerebral Blood Flow Dynamics and Bioelectric Activity of the Human Brain in Experimental Acute Hypoxia. Human Physiology 28, 657–663 (2002). https://doi.org/10.1023/A:1021140020234

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  • DOI: https://doi.org/10.1023/A:1021140020234

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