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MRI screening for breast cancer in women with familial or genetic predisposition: design of the Dutch National Study (MRISC)

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Abstract

Mammography screening of women aged 50–70 years for breast cancer has proven to be effective in reducing breast cancer mortality. There is no consensus about the value of breast cancer screening in women aged 40–49 years. Five to ten per cent of all breast cancers are hereditary. One of the options to reduce the risk of breast cancer mortality for women with a familial or genetic predisposition is intensive surveillance. However, the effectiveness of mammography screening for breast cancer in these women, who are mainly younger than 50 years, is unproven. MRI might increase the effectiveness of screening in women with a familial or genetic predisposition. This paper describes the design of the Dutch national study for Magnetic Resonance Imaging (MRI) screening in women with a familial or genetic predisposition. The aims of this study are to investigate: the value of regular surveillance in women with a familial or genetic predisposition for breast cancer, the efficacy of MRI as compared to mammography, cost-effectiveness of regular screening and quality of life during surveillance. Included are women with a lifetime risk of familial breast cancer of 15% or more or BRCA1/2 mutation carriers, who visit one of the Dutch family cancer clinics. The aim is to include 2,500 women. The study started on 1 November 1999. On 1 January 2002, more than 1700 women, including 210 proven carriers of a BRCA1 or BRCA2 mutation, were included in the study.

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References

  1. Visser O, Coebergh JWW, Schouten LJ et al. (eds). Incidence of cancer in The Netherlands 1996. Utrecht: The Netherlands Cancer Registry, 2000.

    Google Scholar 

  2. Coebergh JWW, van der Heijden LH, Jansen-Heijnen MLG (eds). Cancer incidence and survival in the southeast of The Netherlands 1955-1994. Eindhoven: The Eindhoven Cancer Registery, 1995.

    Google Scholar 

  3. Fletcher SW, Black W, Harris R et al. Report of the international workshop on screening for breast cancer. J Nat Cancer Inst 1993; 85: 1644-56.

    Google Scholar 

  4. Tabar L, Fagerberg G, Chen H-H et al. Efficacy of breast cancer screening by age. New results from the Swedish two-country trial. Cancer 1995; 75: 2507-17.

    Google Scholar 

  5. . Olsen O, Gøtzsche PC. Cochrane review on screening for breast cancer with mammography. Lancet 2001; 358: 1340-42.

    Google Scholar 

  6. Nyström L, Andersson I, Bjurstam N et al. Long-term effects of mammography screening: updated overview of the Swedish randomised trials. Lancet 2002; 359: 909-19.

    Google Scholar 

  7. de Koning HJ, Boer R, Warmerdam PG et al. Quantitative interpretation of age-specific mortality reductions from the swedish breast cancer-screening trials. J Nat Cancer Inst 1995; 87: 1217-23.

    Google Scholar 

  8. Report of the Organizing Committee and Collaborators, Falun Meeting, Falun, Sweden (21 and 22 March, 1996). Breast-cancer screening with mammography in women aged 40-49 years. Int J Cancer 1996; 68: 693-9.

    Google Scholar 

  9. Elmore JG, Barton MB, Moceri VM et al. Ten year risk of false positive screening mammograms and clinical breast examinations. New Eng J Med 1998; 338: 1089-96.

    Google Scholar 

  10. Verhoog LC, van den Ouweland AMW, Berns E et al. Large regional differences in the frequency of distinct BRCA1/BRCA2 mutations in 517 Dutch breast and/or ovarian cancer families. Eur J Cancer 2001; 37: 2082-90.

    Google Scholar 

  11. Easton DF, Ford D, Bishop T and the Breast Cancer Linkage Consortium. Breast and ovarian cancer incidence in BRCA1-mutation carriers. Am J Hum Genet 1995; 56: 265-71.

    Google Scholar 

  12. Ford D, Easton DF, Stratton M et al. Genetic Heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 1998; 62: 676-89.

    Google Scholar 

  13. Brekelmans CTM, Seynaeve C, Bartels CCM et al. Effectiveness of breast cancer surveillance in BRCA1/2 gene mutation carriers and women with high family risk. J Clin Oncol 2001; 19: 924-30.

    Google Scholar 

  14. Chart PL, Franssen E. Management of women at increased risk for breast cancer: preliminary results from a new programme. Can Med Assoc J 1997; 157: 1235-42.

    Google Scholar 

  15. Lai M-S, Yen M-F, Kuo H-S et al. Efficacy of breast cancer screening for female relatives of breast cancer index cases: Taiwan multicentre cancer screening (TAMCAS). Int J Cancer; 1998: 78, 21-6.

    Google Scholar 

  16. Macmillan RD. Screening women with a familial history of breast cancer results from the British Familial Breast Cancer Group. Eur J Surg Oncol; 2000, 26: 149-52.

    Google Scholar 

  17. Moller P, Maehle L, Dorum A et al. Inherited breast carcinoma. Prospective findings in 1194 women at risk. Acta Oncol 1996; Supplementum 8: 7-11.

    Google Scholar 

  18. Tilanus-Linthorst MMA, Bartels CCM, Obdeijn AIM et al. Earlier detection of breast cancer by surveillance of women at familial risk. Eur J Cancer 2000; 36: 514-19.

    Google Scholar 

  19. Kerlikowske K, Carney PA, Geller B et al. Performance of screening mammography among women with and without a first-degree relative with breast cancer. Ann Intern Med 2000; 133: 855-63.

    Google Scholar 

  20. Kerlikowske K, Grady D, Barclay J et al. Effect of age, breast density, and family history on the sensitivity of first screening mammography. JAMA 1996; 276: 33-8.

    Google Scholar 

  21. Mandelson MT, Oestriecher N, Porter PL et al. Breast density as a predictor of mammographic detection: comparison of interval-and screen-detected cancers. J Nat Cancer Inst 2000; 92: 1081-87.

    Google Scholar 

  22. Harms SE. Breast Magnetic Resonance Imaging. Seminars in ultrasound, CT, and MRI 1998; 19: 104-20.

    Google Scholar 

  23. Heywang-Kobrunner SH, Viehweg P, Heinig A et al. Contrast-enhanced MRI of the breast; accuracy, value, controversies, solutions. Eur J Radiol 1997; 24: 94-108.

    Google Scholar 

  24. Orel SG, Schnall MD. MR Imaging of the breast for the detection, diagnosis, and staging of breast cancer. Radiology 2001; 220: 13-30.

    Google Scholar 

  25. Kuhl CK, Schmutzler RK, Leutner CC et al. Breast MR Imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: preliminary results. Radiology 2000; 215: 267-79.

    Google Scholar 

  26. Meijers-Heijboer H, van Geel B, van Putten WLJ et al. Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation. New Eng J Med 2001; 345: 159-64.

    Google Scholar 

  27. Stoutjesdijk MJ, Boetes C, Jager GJ et al. Magnetic resonance imaging and mammography in women with a hereditary risk of breast cancer. J Nat Cancer Inst 2001; 93: 1095-102.

    Google Scholar 

  28. Tilanus-Linthorst MMA, Obdeijn IMM, Bartels CCM et al. First experiences in screening women at high risk for breast cancer with MR imaging. Br Cancer Res Treatm 2000; 63: 53-60.

    Google Scholar 

  29. Warner E, Plewes DB, Shumak RS et al. Comparison of breast magnetic resonance imaging, mammography, and ultrasound for surveillance of women at high risk for hereditary breast cancer. J Clin Oncol 2001; 19: 3524-31.

    Google Scholar 

  30. Brown J, Buckley D, Coulthard A. Magnetic resonance imaging screening in women at genetic risk of breast cancer: imaging and analysis protocol for the UK multicentre study. Magn Res Imag 2000; 18: 765-76.

    Google Scholar 

  31. Bick U. Integriertes Früherkenungskonzept bei Frauen mit genetischer Prädisposition für Burstkrebs. Radiologe 1997; 37: 591-96.

    Google Scholar 

  32. van Oortmarssen GJ, Habbema JD, van der Maas PJ et al. A model for breast cancer screening. Cancer 1990; 66: 1601-12.

    Google Scholar 

  33. Claus EB, Risch N, Thompson WD. Autosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction. Cancer 1994; 73: 643-51.

    Google Scholar 

  34. Kopans DB, Dórsi CJ, Adler DD et al. Breast Imaging Reporting and Data System (BI-RADStm). 2nd ed. Reston (VA): American College of Radiology, 1995.

    Google Scholar 

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Authors and Affiliations

  1. Rotterdam Family Cancer Clinic, Erasmus MC (University Medical Centre Rotterdam)/Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands

    M. Kriege, C. T. M. Brekelmans & J. G. M. Klijn

  2. Department of Radiology, University Medical Centre Nijmegen, The Netherlands

    C. Boetes

  3. Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands

    E. J. T. Rutgers

  4. Department of Clinical Genetics, University Hospital Groningen, The Netherlands

    J. C. Oosterwijk

  5. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands

    R. A. E. M. Tollenaar

  6. Department of Radiology, VU University Medical Centre, Amsterdam, The Netherlands

    R. A. Manoliu

  7. Department of Pathology, University Medical Centre Nijmegen, The Netherlands

    R. Holland

  8. Department of Public Health, Erasmus MC (University Medical Centre Rotterdam), The Netherlands

    H. J. de Koning

Authors
  1. M. Kriege
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  2. C. T. M. Brekelmans
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  3. C. Boetes
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  4. E. J. T. Rutgers
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  5. J. C. Oosterwijk
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  6. R. A. E. M. Tollenaar
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  7. R. A. Manoliu
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  8. R. Holland
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  9. H. J. de Koning
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  10. J. G. M. Klijn
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Kriege, M., Brekelmans, C.T.M., Boetes, C. et al. MRI screening for breast cancer in women with familial or genetic predisposition: design of the Dutch National Study (MRISC). Familial Cancer 1, 163–168 (2001). https://doi.org/10.1023/A:1021135809870

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  • DOI: https://doi.org/10.1023/A:1021135809870

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