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Sucrose-Stimulated Release of FITC-Dextran into the Bile in the Dynamics of Its Storage and Elimination from the Liver

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Abstract

Stimulation of release of FITC-dextran endocytosed in the liver by an injection of hypertonic sucrose led to the appearance of a less pronounced and prolonged peak (with the maximum at min 15-25) at later terms after injection of the marker (30 days). Biliary release of FITC-dextran was 4-9-fold accelerated on days 1-14 in comparison with the constitutive release, and after 30 days it was accelerated 19-fold, which reflects high capacity of the long storage compartment to stimulated release of FITC-dextran into the bile.

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Authors and Affiliations

  1. Central Research Laboratory, Novosibirsk State Medical Academy, Russia

    A. B. Pupyshev & V. I. Maiborodina

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  1. A. B. Pupyshev
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  2. V. I. Maiborodina
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Pupyshev, A.B., Maiborodina, V.I. Sucrose-Stimulated Release of FITC-Dextran into the Bile in the Dynamics of Its Storage and Elimination from the Liver. Bulletin of Experimental Biology and Medicine 134, 139–144 (2002). https://doi.org/10.1023/A:1021128029648

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