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Asperenone: an inhibitor of 15-lipoxygenase and of human platelet aggregation from Aspergillus niger

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Abstract

Asperenone was isolated from the fermented broth of Aspergillus niger CFTRI 1105 and acted as an inhibitor of soybean 15-lipoxygenase (15-LOX) and human platelet aggregation. The IC50 values against 15-LOX and human platelet aggregation were 0.3 mM and 0.23 mM, respectively.

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Authors and Affiliations

  1. Fermentation Technology and Bioengineering Department, India

    K.C. Sekhar Rao, S. Divakar, N.G. Karanth & A.P. Sattur

  2. Protein Chemistry and Technology Department, India

    A.G. Appu Rao

  3. Biochemistry and Nutrition Department, Central Food Technological Research Institute, M, ysore, 570 013, India

    W.J. Suneetha & T.P. Krishnakantha

Authors
  1. K.C. Sekhar Rao
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  2. S. Divakar
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  3. A.G. Appu Rao
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  4. N.G. Karanth
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  5. W.J. Suneetha
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  6. T.P. Krishnakantha
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  7. A.P. Sattur
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Sekhar Rao, K., Divakar, S., Appu Rao, A. et al. Asperenone: an inhibitor of 15-lipoxygenase and of human platelet aggregation from Aspergillus niger . Biotechnology Letters 24, 1967–1970 (2002). https://doi.org/10.1023/A:1021125731940

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  • DOI: https://doi.org/10.1023/A:1021125731940

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