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The Adaptive Effects of Hypoxic Preconditioning of Brain Neurons

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Abstract

A preventive short-term hypoxia (preconditioning) increases neuronal resistance against subsequent strong hypoxic effects. Literature review and authors' own data on molecular-cellular mechanisms of the hypoxic preconditioning, are presented. Participation of intracellular signal transduction, genome, stress-proteins, and neuromodulating peptides in this process, is discussed. The role of glutamatergic as well as calcium and phosphoinositide regulatory systems and neuromodulating factors as the components of a “volume” signal transmission are analyzed in hypoxic precondition-associated induction of functional tolerance mechanisms against acute harmful effects in neurones of olfactory slices.

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Authors and Affiliations

  1. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034, St. Petersburg, Russia

    M. O. Samoilov, D. G. Semenov, A. A. Mokrushin, E. I. Tyul'kova, D. Yu. Romanovskii, E. A. Milyakova & K. N. Dudkin

  2. Medical Research Center, Polish Academy of Sciences, Warsaw, Poland

    E. V. Lazarevich

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  1. M. O. Samoilov
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Samoilov, M.O., Lazarevich, E.V., Semenov, D.G. et al. The Adaptive Effects of Hypoxic Preconditioning of Brain Neurons. Neurosci Behav Physiol 33, 1–11 (2003). https://doi.org/10.1023/A:1021119112927

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