Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 134, Issue 2, pp 107–116 | Cite as

Modern Concept on the Role of Phagocytes in the Pathogenesis of Complications during Pregnancy

  • G. T. Sukhikh
  • V. G. Safronova
  • L. V. Van'ko
Article

Abstract

Here we review modern concept of the role of phagocytes, the key cell component of natural immunity, in the course of pregnancy and in the pathogenesis of its complications. Phagocytes contribute to the development, maintenance, and favorable outcome of pregnancy. These cells play a role in the pathogenesis of various pregnancy complications, including fetal growth retardation, late gestosis, and intrauterine infections. The understanding of the pathophysiological mechanisms that occur in the mother-placenta-fetus system would allow us to improve diagnostic procedures, perform pathogenetically substantiated therapy, and decrease the incidence of obstetrical complications.

pregnancy complication natural immunity phagocytes 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    T. E. Akopyan, Akush. Gin., 6, 3–5 (1996).Google Scholar
  2. 2.
    T. E. Belokrinitskaya and Yu. A. Vitkovskii, Ibid., 4, 32–35 (1999).Google Scholar
  3. 3.
    Yu. A. Vitkovskii, T. E. Belokrinitskaya, and B. I. Kuznik, Ibid., 3, 13–15 (1998).Google Scholar
  4. 4.
    V. I. Govallo, Immunology of Reproduction [in Russian], Moscow (1987).Google Scholar
  5. 5.
    V. I. Kulakov, and L. E. Murashko, Akush. Gin., 2, 3–6 (1996).Google Scholar
  6. 6.
    A. V. Meshcheryakova, E. M. Demidova, T. A. Starostina, et al., Ibid., 3, 22–24 (2001).Google Scholar
  7. 7.
    A. P. Milovanov, Pathology of the Mother—Placenta—Fetus System [in Russian], Moscow (1999).Google Scholar
  8. 8.
    G. I. Muzya, V. I. Kulikov, L. V. Van'ko, et al., Akush. Gin., 3, 12–16 (1996).Google Scholar
  9. 9.
    N. L. Piganova and V. A. Golubev, Ibid., 2, 9–12 (1998).Google Scholar
  10. 10.
    L. V. Posiseeva, I. A. Panova, Yu. S. Antsiferova, et al., Ibid., 5, 26–28 (1998).Google Scholar
  11. 11.
    N. K. Tetruashvili, Diagnostic and Prognostic Significance of Cytokine Assay in Patients with Repeated Pregnancy Loss, Abstract of Cand. Med. Sci. Dissertation, Moscow (1999).Google Scholar
  12. 12.
    A. V. Tyagunova, Z. V. Vasil'eva, O. P. Slastin, et al., Klin. Lab. Diagn., No. 4, 38–40 (1998).Google Scholar
  13. 13.
    E. R. Chernykh, O. Yu. Leplina, E. Ya. Shevela, et al., Akush. Gin., 2, 21–23 (1996).Google Scholar
  14. 14.
    L. L. Arnold, T. M. Doherty, A. W. Flor, et al., Am. J. Reprod. Immunol., 41, 174–182 (1999).Google Scholar
  15. 15.
    A. Barden, D. Graham, L. J. Beilin, et al., Clin. Sci. (Colch)., 92, 37–44 (1997).Google Scholar
  16. 16.
    A. Barden, J. Ritchie, B. Walters, et al., Hypertension., 38, 803–808 (2001).Google Scholar
  17. 17.
    L. N. Berge, M. Ostensen, and A. Revhaug, Acta Obstet. Gynecol. Scand., 67, 499–504 (1988).Google Scholar
  18. 18.
    S. Bettin, H. Halle, B. M. Wenzkowski, et al., Zentralbl. Gynakol., 116, 260–262 (1994).Google Scholar
  19. 19.
    K. Bry and M. Hallman, J. Perinatol., 9, 60–65 (1989).Google Scholar
  20. 20.
    J. N. Bulmer, Baillieres Clin. Obstet. Gynaecol., 6, 461–488 (1992).Google Scholar
  21. 21.
    M. R. Burk, C. Troeger, R. Brinkhaus, et al., Placenta., 22, 309–316 (2001).Google Scholar
  22. 22.
    D. A. Calhoun and R. D. Christensen, Am. J. Obstet. Gynecol., 179, 766–771 (1998).Google Scholar
  23. 23.
    G. Chen and R. Wilson, G. Cumming, et al., Ibid., 169, 1106–1111 (1993).Google Scholar
  24. 24.
    C. J. Clark, F. Boswell, I. A. Greer, et al., J. Soc. Gynecol. Investig., 4, 27–33 (1997).Google Scholar
  25. 25.
    I. P. Crocker, P. N. Baker and J. Fletcher, Ann. Rheum. Dis., 59, 555–564 (2000).Google Scholar
  26. 26.
    I. Crocker, N. Lawson, I. Daniels, et al., Clin. Diagn. Lab. Immunol., 6, 587–593 (1999).Google Scholar
  27. 27.
    I. P. Crocker, R. P. Wellings, J. Fletcher, et al., Br. J. Obstet. Gynaecol., 106, 822–828 (1999).Google Scholar
  28. 28.
    I. P. Crocker, R. P. Wellings, R. G. Hayman, et al., Am. J. Obstet. Gynecol., 179, 1305–1311 (1998).Google Scholar
  29. 29.
    S. P. Crouch, I. P. Crocker, and J. Fletcher, J. Immunol., 155, 5436–5443 (1995).Google Scholar
  30. 30.
    M. J. Cuadrado, C. Lopez-Pedrera, M. A. Khamashta, et al., Arthritis Rheum., 40, 834–841 (1997).Google Scholar
  31. 31.
    P. von Dadelszen, R. W. Watson, F. Noorwali, et al., Am. J. Obstet. Gynecol., 181, 408–414 (1999).Google Scholar
  32. 32.
    Y. Daniel, M. J. Kupferminc, A. Baram, et al., Am. J. Reprod. Immunol., 39, 376–380 (1998).Google Scholar
  33. 33.
    D. Davis, R. Kaufmann, and E. J. Moticka, J. Reprod. Immunol., 40, 119–128 (1998).Google Scholar
  34. 34.
    B. J. Doss, M. F. Greene, J. Hill, et al., Hum. Pathol., 26, 1245–1251 (1995).Google Scholar
  35. 35.
    M. T. Gervasi, T. Chaiworapongsa, N. Naccasha, et al., Am. J. Obstet. Gynecol., 185, 1124–1129 (2001).Google Scholar
  36. 36.
    M. T. Gervasi, T. Chaiworapongsa, P. Pacora, et al., Ibid., 185, 792–797 (2001).Google Scholar
  37. 37.
    J. P. Granger, B. T. Alexander, M. T. Llinas, et al., Hypertension., 38, 718–722 (2001).Google Scholar
  38. 38.
    M. Haeger, M. Unander, B. Norder-Hansson, et al., Obstet. Gynecol., 79, 19–26 (1992).Google Scholar
  39. 39.
    A. Halim, N. Kanayama, E. El Maradny, et al., Am. J. Hypertens., 9, 33–38 (1996).Google Scholar
  40. 40.
    J. Hitti, S. L. Hillier, K. J. Agnew, et al., Obstet. Gynecol., 97, 211–219 (2001).Google Scholar
  41. 41.
    J. S. Hunt, Am. J. Reprod. Immunol., 21, 119–122 (1989).Google Scholar
  42. 42.
    P. Jaremo, T. L. Lindahl, C. Lennmarken, et al., Eur. J. Clin. Invest., 30, 1113–1118 (2000).Google Scholar
  43. 43.
    M. C. Korbage de Araujo, R. Schultz, L. do Rosario Dias de Oliveira, et al., Early Hum. Dev., 56, 1–15 (1999).Google Scholar
  44. 44.
    A. Kotiranta-Ainamo, M. Apajasalo, M. Pohjavuori, et al., Clin. Exp. Immunol., 115, 309–314 (1999).Google Scholar
  45. 45.
    Y. W. Loke and A. King, J. Reprod. Fertil. (Suppl.), 55, 83–90 (2000).Google Scholar
  46. 46.
    A. Lopez Bernal, S. P. Watson, S. Phaneuf, et al., Baillieres Clin. Obstet. Gynaecol., 7, 523–552 (1993).Google Scholar
  47. 47.
    S. Lurie, E. Frenkel, and Y. Tuvbin, Gynecol. Obstet. Invest., 45, 229–231 (1998).Google Scholar
  48. 48.
    M. Makhseed, R. Raghupathy, F. Azizieh, et al., Am. J. Reprod. Immunol., 42, 273–281 (1999).Google Scholar
  49. 49.
    A. Malinowski, M. Szpakowski, K. Zeman, et al., Ginekol. Pol., 68, 232–239 (1997).Google Scholar
  50. 50.
    A. Malinowski, J. Wilczynski, K. Zeman, et al., Zentralbl. Gynakol., 120, 493–502 (1998).Google Scholar
  51. 51.
    M. Massobrio, C. Benedetto, E. Bertini, et al., Am. J. Obstet. Gynecol., 152, 578–583 (1985).Google Scholar
  52. 52.
    S. Matsubara, T. Yamada, H. Minakami, et al., Gynecol. Obstet. Invest., 45, 35–40 (1998).Google Scholar
  53. 53.
    S. Matsubara, T. Yamada, H. Minakami, et al., Placenta., 20, 185–188 (1999).Google Scholar
  54. 54.
    P. B. Medawar, Symp. Soc. Exp. Biol., 7, 320–338 (1953).Google Scholar
  55. 55.
    J. R. Mellembakken, P. Aukrust, K. Hestdal, et al., Hypertension., 38, 394–398 (2001).Google Scholar
  56. 56.
    J. R. Mellembakken, P. Aukrust, M. K. Olafsen, et al., Ibid., 39, 155–160 (2002).Google Scholar
  57. 57.
    J. R. Mellembakken, K. Hogasen, T. E. Mollnes, et al., Obstet. Gynecol., 97, 371–374 (2001).Google Scholar
  58. 58.
    H. Narahara and J. M. Johnston, Am. J. Obstet. Gynecol., 169, 531–537 (1993).Google Scholar
  59. 59.
    E. R. Norwitz, A. Lopez Bernal, and P. M. Starkey, Ibid., 167, 815–820 (1992).Google Scholar
  60. 60.
    E. R. Norwitz, P. M. Starkey, and A. Lopez Bernal, Obstet. Gynecol., 80, 440–445 (1992).Google Scholar
  61. 61.
    A. M. Oudesluys-Murphy, J.C. den Hollander, and W.C. Hop, Biol. Neonate., 58, 236–240 (1990).Google Scholar
  62. 62.
    K. C. Quack, N. Vassiliadou, J. Pudney, et al., Hum. Reprod., 16, 949–955 (2001).Google Scholar
  63. 63.
    I. Rebelo, F. Carvalho-Guerra, L. Pereira-Leite, et al., Eur. J. Obstet. Gynecol. Reprod. Biol., 64, 167–173 (1996).Google Scholar
  64. 64.
    C. W. Redman, Baillieres Clin. Obstet. Gynaecol., 6, 601–615 (1992).Google Scholar
  65. 65.
    C. W. Redman, G. P. Sacks, and I. L. Sargent, Am. J. Obstet. Gynecol., 180, 499–506 (1999).Google Scholar
  66. 66.
    F. Reister, H. G. Frank, W. Heyl, et al., Placenta., 20, 229–233 (1999).Google Scholar
  67. 67.
    F. Reister, H. G. Frank, J. C. Kingdom, et al., Lab. Invest., 81, 1143–1152 (2001).Google Scholar
  68. 68.
    R. Romero, M. Ceska, C. Avila, et al., Am. J. Obstet. Gynecol., 165, 813–820 (1991).Google Scholar
  69. 69.
    S. Russwurm, M. Wiederhold, M. Oberhoffer, et al., Z. Geburtshilfe Neonatol., 204, 34–38 (2000).Google Scholar
  70. 70.
    F. Sabatier, F. Bretelle, C. D'ercole, et al., Am. J. Obstet. Gynecol., 183, 1558–1563 (2000).Google Scholar
  71. 71.
    G. P. Sacks, L. M. Clover, D.R. Bainbridge, et al., Placenta, 22, 550–559 (2001).Google Scholar
  72. 72.
    G. Sacks, I. Sargent, and C. Redman, Immunol. Today, 20, 114–118 (1999).Google Scholar
  73. 73.
    G. P. Sacks, K. Studena, K. Sargent, et al., Am. J. Obstet. Gynecol., 179, 80–86 (1998).Google Scholar
  74. 74.
    J. E. Sampson, R. P. Theve, R. N. Blatman, et al., Ibid., 176, 77–81 (1997).Google Scholar
  75. 75.
    R. J. Scott, D. Peat, and C. A. Rhodes, Pediatr. Pathol., 14, 997–1003 (1994).Google Scholar
  76. 76.
    N. J. Sebire, S. G. Carroll, M. Newbold, et al., J. Matern. Fetal. Med., 5, 227–231 (1996).Google Scholar
  77. 77.
    A. M. Sharkey, D. S. Charnock-Jones, C. A. Boocock, et al., J. Reprod. Fertil., 99, 609–615 (1993).Google Scholar
  78. 78.
    S. D. Shelton, K. A. Boggess, K. Kirvan, et al., Obstet. Gynecol., 97, 583–586 (2001).Google Scholar
  79. 79.
    A. Sienko and G. Altshuler, Ibid., 94, 415–420 (1999).Google Scholar
  80. 80.
    A. K. Smarason, K. G. Allman, D. Young, et al., Br. J. Obstet. Gynaecol., 104, 538–543 (1997).Google Scholar
  81. 81.
    C. M. Spickett, W. E. Smith, J. Reglinski, et al., Clin. Chim. Acta., 270, 115–124 (1998).Google Scholar
  82. 82.
    A. Steinborn, C. Sohn, C. Sayehli, et al., Clin. Exp. Immunol., 117, 147–152 (1999).Google Scholar
  83. 83.
    A. Steinborn, C. von Gall, R. Hildenbrand, et al., Obstet. Gynecol., 91, 329–335 (1998).Google Scholar
  84. 84.
    A. Steinborn, C. Sohn, C. Sayehli, et al., Clin. Immunol., 100, 305–313 (2001).Google Scholar
  85. 85.
    J. R. Steinert, A. W. Wyatt, L. Poston, et al., FASEB J., 16, 721–723 (2002).Google Scholar
  86. 86.
    R. Straussberg, L. Sirota, J. Hart, et al., Biol. Neonate., 68, 15–18 (1995).Google Scholar
  87. 87.
    B. Thilaganathan, K. Stagiannis, N. J. Meher-Homji, et al., Fetal. Diagn. Ther., 9, 79–83 (1994).Google Scholar
  88. 88.
    K. Tsukimori, H. Maeda, K. Ishida, et al., Obstet. Gynecol., 81, 536–540 (1993).Google Scholar
  89. 89.
    J. G. Vallejo, P. Knuefermann, D.L. Mann, et al., J. Immunol., 165, 419–425 (2000).Google Scholar
  90. 90.
    D. Vinatier and J. C. Monnier, Eur. J. Obstet. Gynecol. Reprod. Biol., 61, 85–97 (1995).Google Scholar
  91. 91.
    G. S. Vince and P. M. Johnson, Biochem. Soc. Trans., 28, 191–195 (2000).Google Scholar
  92. 92.
    D. S. Vince and P.M. Johnson, Placenta, 17, 191–196 (1996).Google Scholar
  93. 93.
    S. Visvanathan, C. L. Geczy, J. A. Harmer, et al., J. Immunol., 165, 2258–2262 (2000).Google Scholar
  94. 94.
    P. Vural, Clin. Chim. Acta, 317, 65–70 (2002).Google Scholar
  95. 95.
    J. J. Walker, Semin. Reprod. Endocrinol., 16, 47–55 (1998).Google Scholar
  96. 96.
    Y. Wang, C. D. Adair, L. Coe, et al., J. Soc. Gynecol. Investig., 5, 237–243 (1998).Google Scholar
  97. 97.
    Y. Wang, C. D. Adair, J. W. Weeks, et al., Ibid., 6, 136–141 (1999).Google Scholar
  98. 98.
    Y. Wang, Y. Gu, L. Philibert, et al., Placenta, 22, 560–565 (2001).Google Scholar
  99. 99.
    T. G. Wegmann, H. Lin, L. Guilbert, et al., Immunol. Today., 14, 353–356 (1993).Google Scholar
  100. 100.
    B. Wetzka, R. Nusing, D. S. Charnock-Jones, et al., Hum. Reprod., 12, 2313–2320 (1997).Google Scholar
  101. 101.
    T. Yamada, S. Matsubara, H. Minakami, et al., Acta Obstet. Gynecol. Scand., 79, 818–239 (2000).Google Scholar
  102. 102.
    T. Yamada, H. Minakami, S. Matsubara, et al., J. Reprod. Immunol., 46, 21–30 (2000).Google Scholar
  103. 103.
    T. Yamada, H. Minakami, S. Matsubara, et al., Gynecol. Obstet. Invest., 45, 32–34 (1998).Google Scholar
  104. 104.
    G. R. Yeaman, J. E. Collins, J. K. Currie, et al., J. Immunol., 160, 5145–5153 (1998).Google Scholar
  105. 105.
    B. H. Yoon, R. Romero, J. S. Park, et al., Am. J. Obstet. Gynecol., 183, 1124–1129 (2000).Google Scholar
  106. 106.
    P. L. Zusterzeel, G. J. Wanten, W. H. Peters, et al., Eur. J. Obstet. Gynecol. Reprod. Biol., 99, 213–218 (2001).Google Scholar

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • G. T. Sukhikh
    • 1
    • 2
  • V. G. Safronova
    • 1
    • 2
  • L. V. Van'ko
    • 1
    • 2
  1. 1.Research Center for Obstetrics, Gynecology, and PerinatologyRussian Academy of Medical SciencesMoscow
  2. 2.Institute of Cell BiophysicsRussian Academy of SciencesPushchino

Personalised recommendations