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Pathomorphological and Immunohistochemical Analysis Biopsy Specimens from Large Bronchi of Patients with Pulmonary Cancer

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Abstract

Biopsy specimens from large bronchi of patients with central and peripheral pulmonary cancer were studied. Central cancer was associated with hyperplasia and dysplasia of the epithelium, hyperplasia of glandular compartment, and pronounced immunocompetent cell response. Peripheral cancer was characterized by predominance of atrophic and sclerotic changes, lymph flow disorders, and tendency to lymphoid aggregation. These data suggest that not only dysplasia, but also the combination of all structural changes typical of each form of pulmonary cancer should be considered as a morphological marker of enhanced risk of tumor development.

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REFERENCES

  1. B. N. Zyryanov, V. S. Siyanov, S. A. Velichko, and N. A. Makarkin, Pulmonary Cancer. New Approaches for Diagnosis and Treatment [in Russian], Tomsk (1997).

  2. E. A. Kogan, Arch. Patol., No. 11, 76–83 (1989).

  3. E. A. Kogan, I. A. Orlova, and G. Zhak, Ibid., No. 2, 6–11 (2001).

  4. E. A. Kogan and D. A. Ugryumov, Ibid., No. 1, 33–37 (2002).

  5. V. A. Krutovskikh, Ibid., No. 1, 3–7 (2000).

  6. G. I. Nepomnyashchikh, V. A. Levitskii, L. M. Nepomnyashchikh, et al., Byull. Eksp. Biol. Med., 129,No. 4, 470–474 (2000).

    Google Scholar 

  7. L. M. Nepomnyashchikh, V. A. Levitskii, G. I. Nepomnyashchikh, et al., Ibid., No. 3, 347–351 (2000).

    Google Scholar 

  8. M. A. Pal'tsev, S. A. Demura, E. A. Kogan, et al., Ibid., 130,No. 7, 98–101 (2000).

    Google Scholar 

  9. Pathoanatomical Diagnosis of Human Tumors, Eds. N. A. Kraevskii, et al. [in Russian], Moscow (1993).

  10. A. Kh. Trakhtenberg and V. I. Chissov, Clinical Oncopulmonology [in Russian], Moscow (2000).

  11. M. Emoto, Y. Emoto, and S. Kaufman, Immunology, 88,No. 4, 531–536 (1996).

    Google Scholar 

  12. K. Fong, Y. Sekido, and J. Minna, J. Thorac. Cardiovasc. Surg., 118,No. 6, 1136–1152 (1999).

    Google Scholar 

  13. F. Hirch, W. Franklin, A. Gazdar, and P. Bunn, Clin. Cancer Res., 7,No. 1, 5–22 (2001).

    Google Scholar 

  14. H. Yamasaki and C. Naus, Carcinogenesis, 17, 1199–1213 (1996).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Ultrastructural Bases of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    G. I. Nepomnyashchikh, V. A. Levitskii, A. K. Dolgovykh & L. A. Naumova

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  1. G. I. Nepomnyashchikh
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  2. V. A. Levitskii
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  3. A. K. Dolgovykh
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  4. L. A. Naumova
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Nepomnyashchikh, G.I., Levitskii, V.A., Dolgovykh, A.K. et al. Pathomorphological and Immunohistochemical Analysis Biopsy Specimens from Large Bronchi of Patients with Pulmonary Cancer. Bulletin of Experimental Biology and Medicine 134, 198–202 (2002). https://doi.org/10.1023/A:1021108920079

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  • DOI: https://doi.org/10.1023/A:1021108920079

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