REFERENCES
Simonetti RG, Camma C, Fiorello F, et al: Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis: a case control study. Ann Intern Med 1166:97–102
Yu MW, You SL, Chang AS, et al: Association between hepatitis C virus antibodies and hepatocellular carcinoma in Taiwan. Cancer Res 51:5621–5662, 1999
Ikeda K, Saitoh S, Koida I: A multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis. Hepatology 18:47–53, 1993
Peng YC, Chan CS, Chen GH: The effectiveness of serum α-fetoprotein level in anti-HCV positive patients for screening hepatocellular carcinoma. Hepato-Gastroenterol 46:3208–3211, 1999
Fook-Hong N, Kai-Chiu C, Chi-Sing C, et al: High α-fetoprotein level in HCV-related nodular liver cell dysplasia. Am J Gastroenterol 94:2296–2297, 1999
Okuda K: Clinical aspects of hepatocellular carcinoma: analysis of 134 cases. In K, Okuda RL, Peters (eds). Hepatocellular Carcinoma. New York, John Wiley & Sons, 1976, p 387
Kew MC, Newburne PM: Tumor markers in hepatocellular carcinoma. In K Okuda, IR Mackay (eds). Hepatocellular Carcinoma. Geneva, Unione Internationale Contre le Cancer, 1982, p 123
Okuda K, et al: Clinical observations during a relatively early stage of hepatocellular carcinoma, with special reference to serum α-fetoprotein levels. Gastroenterology 69:226, 1975
Ebara M, et al: Natural history of minute hepatocellular carcinoma smaller than three centimeters complicating cirrhosis: a study in 22 patients. Gastroenterology 90:289, 1986
Shinagawa T, et al: Diagnosis and clinical features of small hepatocellular carcinoma with emphasis of the utility of realtime ultrasonography: a study of 51 patients. Gastroenterology 86:495, 1984
Taketa K: α-Fetoprotein: reevaluation in hepatology. Hepatology 12:1420, 1990
Chen DS, Sung JL: Serum alpha-fetoprotein in hepatocellular carcinoma. Cancer 40:779–783, 1977
Kato Y, Nakata K, Omagari K, et al: Risk of hepatocellular carcinoma in patients with cirrhosis in Japan: analysis of infectious hepatitis viruses. Cancer 74:2234–2238, 1994
Takano S, Yokosuka O, Imazeki F, et al: Incidence of hepatocellular carcinoma in chronic hepatitis B and C: a prospective study of 251 patients. Hepatology 21:650–655, 1995
Yamada G, Tanaka E, Miura T, et al: Epidemiology of genotypes of hepatitis C virus in Japanese patients with type C chronic liver diseases: multi-institution analysis. J Gastroenterol Hepatol 10:538–545, 1995
DiBisceglie AM: Hepatitis C and hepatocellular carcinoma. Semin Liver Dis 15:64–69, 1995
Weinberg DS, Malet PF: Chronic hepatitis C and markedly elevated serum α-fetoprotein: complete response to treatment with α-interferon. Am J Gastroenterology 89:1253–1254, 1994
McHutchinson JG, Gordon S, Schiff ER, et al: Interferon alfa 2b montherapy versus interferon alfa 2b plus ribavirin as initial treatment for chronic hepatitis C: results of a US multicenter randomized controlled trial. N Engl J Med 339:1485–1492, 1998
Shiffman ML, Hofmann CH, Luketic VA, et al: Gradual reduction in interferon dose reduces the incidence of relapse in patients with chronic hepatitis C: results of a randomized controlled trial. Hepatology 24:21–6, 1996
Davis GL, Balart LA, Schiff ER, et al: Treatment of chronic hepatitis C with recombinant interferon alpha: a multicenter randomized controlled trial. N Engl J Med 321:1501–6, 1989
DiBisceglie AM, Martin P, Kassianides C, et al: Recombinant interferon alfa therapy for chronic hepatitis C. N Engl J Med 321:1506–10, 1989
Marcellin P, Boyer N, Giostra E, et al: Recombinant alphainterferon in patients with chronic non-A, non-B hepatitis: a multicenter randomized controlled trial from France. Hepatology 13:393–7, 1991
Causse X, Godinot H, Chevallier M, et al: Comparison of 1 or 3 mU of interferon alpha-2b and placebo in patients with chronic non-A, non-B hepatitis. Gastroenterology 101:497–502, 1991
Chemello L, Bonetti P, Cavalletto L, et al: Randomized trial comparing three different regimens of alpha-2a-interferon in chronic hepatitis C. Hepatology 22:700–6, 1995
Poynard T, Bedossa P, Chevallier M, et al: A comparison of three interferon alfa-2b regimens for the long-tern treatment of chronic non-A, non-B hepatitis. N Engl J Med 332:1457–62, 1995
Shiffman ML, Hofmann CM, Thompson EB, et al: Relationship between biochemical; virologic and histologic response during interferon treatment of chronic hepatitis C. Hepatology 26:780–5, 1997
Shiffman ML, Hofmann CM, Contos MJ, et al: A randomized controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia. Gastroenterology 117:1164–72, 1999
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stein, D.F., Myaing, M. CASE REPORT: Normalization of Markedly Elevated α-Fetoprotein in a Virologic Nonresponder with HCV-Related Cirrhosis. Dig Dis Sci 47, 2686–2690 (2002). https://doi.org/10.1023/A:1021044803279
Issue Date:
DOI: https://doi.org/10.1023/A:1021044803279