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Site-specific synthetic ribonucleases based on oligonucleotide conjugates with metal-independent organic catalysts of hydrolysis of phosphodiester bonds

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Abstract

The review surveys the results obtained in investigations on the design of site-specific catalysts of the phosphodiester bond cleavage in ribonucleic acids based on deoxyribonucleotide conjugates with peptide mimics.

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Authors and Affiliations

  1. Siberian Branch of the Russian Academy of Sciences, Novosibirsk Institute of Bioorganic Chemistry, 8 prosp. Akad. Lavrent"eva, 630090, Novosibirsk, Russian Federation

    I. Yu. Garipova & V. N. Silnikov

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  1. I. Yu. Garipova
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  2. V. N. Silnikov
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Garipova, I.Y., Silnikov, V.N. Site-specific synthetic ribonucleases based on oligonucleotide conjugates with metal-independent organic catalysts of hydrolysis of phosphodiester bonds. Russian Chemical Bulletin 51, 1112–1117 (2002). https://doi.org/10.1023/A:1020989621857

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