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Oligoribonucleotides containing an aminoalkyl group at the N(4) atom of cytosine as precursors of new reagents for site-specific modifications of biopolymers

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Russian Chemical Bulletin Aims and scope

Abstract

A solid-phase H-phosphonate procedure was developed for the synthesis of oligoribonucleotides containing aliphatic amino linkers with different lengths at the N(4) atom of cytosine. The hybridization properties of modified oligoribonucleotides were studied. Thermal stability of the RNA—RNA* and DNA—RNA* duplexes depends on the position of modified cytosine in the chain and the type of the duplex.

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Authors and Affiliations

  1. Novosibirsk Institute of Bioorganic Chemistry, 8 prosp. Akad. Lavrent"eva, 630090, Novosibirsk, Russian Federation

    M. N. Repkova, M. I. Meshchaninova, T. M. Ivanova, N. I. Komarova, D. V. Pyshnyi & A. G. Venyaminova

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  1. M. N. Repkova
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  2. M. I. Meshchaninova
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  3. T. M. Ivanova
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  4. N. I. Komarova
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  5. D. V. Pyshnyi
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  6. A. G. Venyaminova
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Repkova, M.N., Meshchaninova, M.I., Ivanova, T.M. et al. Oligoribonucleotides containing an aminoalkyl group at the N(4) atom of cytosine as precursors of new reagents for site-specific modifications of biopolymers. Russian Chemical Bulletin 51, 1194–1197 (2002). https://doi.org/10.1023/A:1020988126883

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  • DOI: https://doi.org/10.1023/A:1020988126883

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