References
Rosenfeld RG. Is growth hormone deficiency a viable diagnosis? J Clin Endocrinol Metab 1997;82:349–351.
Camacho-Hübner C, Savage MO. Insulin-like growth factor-I deficiency. Horm Res 2001;55(1,Suppl):17–20.
Savage MO, Blum WF, Ranke MB, Postel-Vinay MC, Cotterill AM, Hall K, Chatelain PG, Preece MA, Rosenfeld RG. Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome). J Clin Endocrinol Metab 1993;77:1465–1471.
Jones JI, Clemmons DR. Insulin-like growth factors, and their binding proteins. Endocr Rev 1995;16:3–34.
Godowski PJ, Leung DW, Meacham LR, Galgani JP, Hellmiss R, Keret R, Rotwein PS, Parks JS, Laron Z, Wood WI. Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism. Proc Natl Acad Sci USA 1989;86:8083–8087.
Woods KA, Dastot F, Preece MA, Clark AJ, Postel-Vinay MC, Chatelain PG, Ranke MB, Rosenfeld RG, Amselem S, Savage MO. Phenotype: Genotype relationships in growth hormone insensitivity syndrome. J Clin Endocrinol Metab 1997;82:3529–3535.
Laron Z, Pertzelan A, Mannheimer S. Genetic pituitary dwarfism with high serum concentration of growth hormone: A new inborn error of metabolism? Isr J Med Sci 1966;2:152–155.
Laron Z, Klinger B. Laron syndrome-clinical features, molecular pathology and treatment. Horm Res 1994;42:198–202.
Baker J, Liu J-P, Robertson EJ, Efstriadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993;75:73–82.
Liu J-P, Baker J, Perkins AS, Robertson EJ, Efstraidis A. Mice carrying null mutations of the genes encoding insulin-like growth factor (igf-i) an type 1 IGF receptor (igf1r). Cell 1993;75:59–72.
Powell-Braxton L, Hollinghead P, Warburton C, Dowd M, Pitts-Meek S, Dalton D, Gillett N, Stewart TA. IGF-I is required for normal embryonic growth in mice. Genes Dev 1993;7:2609–2617.
Liu Junn-Li, Grinberg A, Westphal H, Sauer B, Accili D, Karas M, LeRoith D. Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage dependent manner: Manipulation using the Cre/loxP system in transgenic mice. Mol Endocrinol 1998;12:1452–1462.
Sjögren K, Liu J-L, Blad K, Skrtic S, Vidal O, Wallenius V, LeRoith D, Tornell J, Isaksson OG, Jansson JO, Ohlsson C. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but it is not requires for postnatal growth in mice. Proc Natl Acad Sci 1999;96:7088–7092.
Rotwein PS, Pollock KM, Didier DK, Krivi GG. Organization and sequence of the human insulin-like growth factor I gene. J Biol Chem 1986;261:4828–4932.
Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor-I and its structural homology with proinsulin. J Biol Chem 1978;253:2769–2776.
Walker JL, Ginalska-Malinowska M, Romer TE, Pucilowska JB, Underwood LE. Effects of the infusion of insulin-like growth factor I in a child with growth hormone insensitivity syndrome. N Engl J Med 1991;324:1483–1488.
Backeljauw PF, Underwood LE, The GHIS Collaborative Group. Prolonged treatment with recombinant insulin-like growth factor-I in children with growth hormone insensitivity syndrome-Aclinical research center study. J Clin Endocrinol Metab 1996;81:3312–3317.
Guevara-Aguirre J, Rosenbloom AL, Vasconez O, Martinez V, Gargosky SE, Allen L, Rosenfeld RG. Two-year treatment of growth hormone (GH) receptor deficiency with recombinant insulin-like growth factor I in 22 children: Comparison of two dosage levels and to GH-treated GH deficiency. J Clin Endocrinol Metab 1997;82:629–633.
Ranke MB, Savage MO, Chatelain PG, Preece MA, Rosenfeld RG, Wilton P. Long-term treatment of growth hormone insensitivity syndrome with IGF-I. Horm Res 1999;51:128–134.
Savage MO, Burren CP, Blair JA, Woods KA, Metherell L, Clark AJ, Camacho-Hübner C. Growth hormone insensitivity: pathophysiology, diagnosis, clinical variation and future perspectives. Horm Res 2001;55(Suppl):32–35.
Woods KA, Camacho-Hübner C, Savage MO, Clark AJL. Intrauterine growth retardation and post natal growth failure associated with deletion of the IGF-I gene. N Engl J Med 1996;335:1363–1367.
Camacho-Hübner C, Woods KA, Miraki-Moud F, Hindmarsh PC, Clark AJ, Hansson Y, Johnston A, Baxter RC, Savage MO. Effects of recombinant human insulin-like growth factor (IGF)-I therapy on the growth hormone (GH)-IGF system of a patient with a partial IGF-I gene deletion. J Clin Endocrinol Metab 1999;84:1611–1616.
Woods KA, Camacho-Hübner C, Bergman RN, Barter D, Clark AJ, Savage MO. Effects of insulin-like growth factor I (IGF-I) therapy on body composition and insulin resistance in IGF-I gene deletion. J Clin Endocrinol Metab 2000;85:1407–1411.
Cutfield WS, Bergamn RN, Menon RK, Sperling MA. The modified mininal model: Application to measurement of insulin-sensitivity in children. J Clin Endocrinol Metab 1990;70:1644–1650.
Liu-J-L, Le Roith D. Insulin-like growth factor I is essential for postnatal growth in response to growth hormone. Endocrinology 1999;140:5178–5184.
Cotterill AM, Camacho-Hübner C, Holly JMP, Savage MO. The effect of recombinant human insulin-like growth factor (IGF)-I treatment of growth hormone secretion in two subjects with growth hormone insensitivity (Laron syndrome). Clin Endocrinol (Oxf) 1993;39:119–122.
Lajara R, Galgani JP, Dempsher DP, Bier DM, Rotwein P. Low prevalence of insulin-like growth factor-I gene mutations in human growth hormone disorders. J Clin Endocrinol Metab 1990;70:687–692.
Schneid H, Le Bouc Y, Seurin D, Gourmelen M, Cabrol S, Raux-Demay MC, Girard F, Binoux M. Insulin-like growth factor-I gene analysis in subjects with constitutionally variant stature. Pediatr Res 1990;27:488–491.
Johnston LB, Leger J, Savage MO, Clark AJL, Czernichow P. The insulin-like growth factor-I (IGF-I) gene in individuals born small for gestational age (SGA). Clin Endocrinol 1999;51:423–427.
Arends NJ, Johnston L, Hokken-Koelega A, van Duijn C, de Ridder M, Savage M, Clark A. Transmission disequilibrium of two polymorphic markers in the IGF-I gene in children with short stature born small for gestational age (SGA) AbstractP1–435. Pediatr Res 2001;(Suppl):73A.
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Camacho-Hübner, C., Woods, K.A., Clark, A.J. et al. Insulin-Like Growth Factor (IGF)-I Gene Deletion . Rev Endocr Metab Disord 3, 357–361 (2002). https://doi.org/10.1023/A:1020957809082
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DOI: https://doi.org/10.1023/A:1020957809082