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Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor

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References

  1. Petersenn S, Schulte HM. Structure and function of the growth-hormone-releasing hormone receptor. Vitam Horm 2000;59:35–69.

    Google Scholar 

  2. Muller EE, LocatelliV, Cocchi D. Neuroendocrine control of growth hormone secretion. Physiol Rev 1999;79:511–607.

    Google Scholar 

  3. Tannenbaum GS, Ling N. The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion. Endocrinology 1984;115:1952–1957.

    Google Scholar 

  4. Plotsky PM, Vale W. Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 1985;230:461–463.

    Google Scholar 

  5. Frohman LA, Downs TR, Clarke IJ, Thomas GB. Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. Spontaneous secretion and response to insulin-induced hypoglycemia. J Clin Invest 1990;86:17–24.

    Google Scholar 

  6. Roelfsema F, Biermasz NR, Veldman RG, Veldhuis JD, Frolich M, Stovkis-Brantsma WH, Wit J-M. Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: Evidence for a role for non-GHRH inputs into the generation of GH pulses. J Clin Endocrinol Metab 2001;86:2459–2464.

    Google Scholar 

  7. Issaksson OGP, Isgaard J, Nilsson A, Lindahl A. Direction action of GH. In: BB Bercu, ed. Growth Hormone: Basic and Clinical Aspects. New York: Plenum, 1988;199–211.

    Google Scholar 

  8. Zapf J, Walter H, Froesch ER. Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J Clin Invest 1981;68:1321–1330.

    Google Scholar 

  9. Sjögren K, Liu J-L, Blad K, Skrtic S, Vidal O, Wallenius V, LeRoith D, Törnell J, Isaksson OGP, Jansson J-O, Ohlsson C. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci USA 1999;96:7088–7092.

    Google Scholar 

  10. Yakar S, Liu J-L, Stannard B, Butler A, Accili D, Sauer B, LeRoith D. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 1999;96:7324–7329.

    Google Scholar 

  11. Flavell DM, Wells T, Wells SE, Carmignac DF, Thomas GB, Robinson ICAF. Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. Embo J 1996;15:3871–3879.

    Google Scholar 

  12. Gianotti L, Maccario M, Lanfranco F, Ramunni J, Di Vito L, Grottoli S, Muller EE, Ghigo E, Arvat E. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000;85:3604–3608.

    Google Scholar 

  13. Guillemin R, Brazeau P, Bohlen P, Esch F, Ling N, Wehrenberg WB. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 1982;218:585–587.

    Google Scholar 

  14. Rivier J, Spiess J, Thorner M, Vale W. Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature 1982;300:276–278.

    Google Scholar 

  15. Bloch B, Gaillard RC, Brazeau P, Lin HD, Ling N. Topographical and ontogenetic study of the neurons producing growth hormone-releasing factor in human hypothalamus. Regul Pept 1984;8:21–31.

    Google Scholar 

  16. Argente J, Evain-Brion D, Munoz-Villa A, Garnier P, Hernandez M, Donnadieu M. Relationship of plasma growth hormone-releasing hormone levels to pubertal changes. J Clin Endocrinol Metab 1986;63:680–682.

    Google Scholar 

  17. Russell-Aulet M, Jaffe CA, Demott-Friberg R, Barkan AL. In vivo semiquantification of hypothalamic growth hormone-releasing hormone (GHRH) output in humans: Evidence for relative GHRH deficiency in aging. J Clin Endocrinol Metab 1999;84:3490–3497.

    Google Scholar 

  18. Mayo KE, Godfrey PA, Suhr ST, Kulik DJ, Rahal JO. Growth hormone-releasing hormone: Synthesis and signaling. Rec Prog Horm Res 1995;50:35–73.

    Google Scholar 

  19. Ehlers CL, Reed TK, Henriksen SJ. Effects of corticotropin-releasing factor and growth hormone-releasing factor on sleep and activity in rats. Neuroendocrinology 1986;42:467–474.

    Google Scholar 

  20. Nistico G, De Sarro GB, Bagetta G, Muller EE. Behavioural and electrocortical spectrum power effects of growth hormone releasing factor in rats. Neuropharmacology 1987;26:75–78.

    Google Scholar 

  21. Steiger A, Guldner J, Hemmeter U, Rothe B, Wiedemann K, Holsboer F. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology 1992;56:566–573.

    Google Scholar 

  22. Tannenbaum GS. Growth hormone secretory dynamics in streptozotocin diabetes: Evidence of a role for endogenous circulating somatostatin. Endocrinology 1981;108:76–82.

    Google Scholar 

  23. Riviere P, Bueno L. Influence of regimen and insulinemia on orexigenic effects of GRF1–44 in sheep. Physiol Behav 1987;39:347–350.

    Google Scholar 

  24. Christofides ND, Stephanou A, Suzuki H, Yiangou Y, Bloom SR. Distribution of immunoreactive growth hormone-releasing hormone in the human brain and intestine and its production by tumors. J Clin Endocrinol Metab 1984;59:747–751.

    Google Scholar 

  25. Asa SL, Kovacs K, Thorner MO, Leong DA, Rivier J, Vale W. Immunohistological localization of growth hormone-releasing hormone in human tumors. J Clin Endocrinol Metab 1985;60:423–427.

    Google Scholar 

  26. Bosman FT, Van Assche C, Nieuwenhuyzen Kruseman AC, Jackson S, Lowry PJ. Growth hormone releasing factor (GRF) immunoreactivity in human and rat gastrointestinal tract and pancreas. J Histochem Cytochem 1984;32:1139–1144.

    Google Scholar 

  27. Shibasaki T, Kiyosawa Y, Masuda A, Nakahara M, Imaki T, Wakabayashi I, Demura H, Shizume K, Ling N. Distribution of growth hormone-releasing hormone-like immunoreactivity in human tissue extracts. J Clin Endocrinol Metab 1984;59:263–268.

    Google Scholar 

  28. Margioris AN, Brockmann G, Bohler HC Jr., Grino M, Vamvakopoulos N, Chrousos GP. Expression and localization of growth hormone-releasing hormone messenger ribonucleic acid in rat placenta: In vitro secretion and regulation of its peptide product. Endocrinology 1990;126:151–158.

    Google Scholar 

  29. Gonzalez-Crespo S, Boronat A. Expression of the rat growth hormone-releasing hormone gene in placenta is directed by an alternative promoter. Proc Natl Acad Sci USA 1991;88:8749–8753.

    Google Scholar 

  30. Bagnato A, Moretti C, Ohnishi J, Frajese G, Catt KJ. Expression of the growth hormone-releasing hormone gene and its peptide product in the rat ovary. Endocrinology 1992;130:1097–1102.

    Google Scholar 

  31. Berry SA, Srivastava CH, Rubin LR, Phipps WR, Pescovitz OH. Growth hormone-releasing hormone-like messenger ribonucleic acid and immunoreactive peptide are present in human testis and placenta. J Clin Endocrinol Metab 1992;75:281–284.

    Google Scholar 

  32. Moretti C, Bagnato A, Solan N, Frajese G, Catt KJ. Receptor-mediated actions of growth hormone releasing factor on granulosa cell differentiation. Endocrinology 1990;127:2117–2126.

    Google Scholar 

  33. Ciampani T, Fabbri A, Isidori A, Dufau ML. Growth hormone-releasing hormone is produced by rat Leydig cell in culture and acts as a positive regulator of Leydig cell function. Endocrinology 1992;131:2785–2792.

    Google Scholar 

  34. Stephanou A, Knight RA, Lightman SL. Production of a growth hormone-releasing hormone-like peptide and its mRNA by human lymphocytes. Neuroendocrinology 1991;53:628–633.

    Google Scholar 

  35. Gubler U, Monahan JJ, Lomedico PT, Bhatt RS, Collier KJ, Hoffman BJ, Bohlen P, Esch F, Ling N, Zeytin F, Brazeau P, Poonian MS, Gage LP. Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin. Proc Natl Acad Sci USA 1983;80:4311–4314.

    Google Scholar 

  36. Mayo KE, Vale W, Rivier J, Rosenfeld MG, Evans RM. Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor. Nature 1983;306:86–88.

    Google Scholar 

  37. Mayo KE, Cerelli GM, Lebo RV, Bruce BD, Rosenfeld MG, Evans RM. Gene encoding human growth hormone-releasing factor precursor: Structure, sequence, and chromosomal assignment. Proc Natl Acad Sci USA 1985;82:63–67.

    Google Scholar 

  38. Godfrey P, Rahal JO, Beamer WG, Copeland NG, Jenkins NA, Mayo KE. Ghrhr receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nature Genetics 1993;4:227–231.

    Google Scholar 

  39. Frohman LA, Kineman RD, Kamegai J, Park S, Teixeira LT, Coschigano KT, Kopchic JJ. Secretagogues and the somatotrope: Signaling and proliferation. Recent Prog Horm Res 2000;55:269–290.

    Google Scholar 

  40. Bowers CY, Chang J, Momany FA, Folkers K. Effects of the enkephalins and enkephalin-analog on release of pituitary hormones in vitro. In: Proceedings of 6th International Conference on Endocrinology, Molecular Endocrinology. Amsterdam: Elsevier/ North Holland, 1977.

    Google Scholar 

  41. Giustina A, Bonfanti C, Licini M, Ragni G, Stefana B. Hexarelin, a novel GHRP-6 analog, stimulates growth hormone (GH) release in a GH-secreting rat cell line (GH1) insensitive to GH-releasing hormone. Regul Pept 1997;70:49–54.

    Google Scholar 

  42. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJS, Dean DC, Melillo D, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LHT. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996;273:974–977.

    Google Scholar 

  43. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa, K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656–660.

    Google Scholar 

  44. Tomasetto C, Karam SM, Ribieras S, Masson R, Lefebvre O, Staub A, Alexander G, Chenard MP, Rio MC. Identification and characterization of a novel gastric peptide hormone: The motilin-related peptide. Gastroenterology 2000;119:395–405.

    Google Scholar 

  45. Wajnrajch MP, Ten IS, Gertner JM, Leibel RL. Genomic organization of the GHRELIN gene. J Endo Gen 2000;1:231–233.

    Google Scholar 

  46. Shintani M, Ogawa Y, Ebihara K, Aezawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, Nakao K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001;50:227–232.

    Google Scholar 

  47. Roh SG, Nie GY, Loneragan K, Gertler A, Chen C. Direct modification of somatotrope function by long-term leptin treatment of primary cultured ovine pituitary cells. Endocrinology 2001;142:5167–5171.

    Google Scholar 

  48. Smith RG, Pong SS, Hickey G, Jacks T, Cheng K, Leonard R, Cohen CJ, Arena JP, Chang CH, Drisko J, Wyvratt M, Fisher M, Nargund R, Patchett A. Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland. Recent Prog Horm Res 1996;51:261–285.

    Google Scholar 

  49. Palyha OC, Feighner SD, Tan CP, McKee KK, Hreniuk DL, Gao YD, Schleim KD, Yang L, Morriello GJ, Nargund R, Patchett AA, Howard AD, Smith RG. Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans. Mol Endocrinol 2000;14:160–169.

    Google Scholar 

  50. Cheng K, Chan WW, Barreto A Jr, Convey EM, Smith RG. The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3',5'-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology 1989;124:2791–2798.

    Google Scholar 

  51. Bercu BB, Walker RF. Novel growth hormone secretagogues: Clinical applications. The Endocrinologist 1997;7:51–64.

    Google Scholar 

  52. Tolis G, Karydis I, Markousis V, Karagiorga M, Mesimeris T, Lenaerts V, Deghenghi R. Growth hormone release by the novel GH releasing peptide hexarelin in patients with homozygous β-thalassemia. J Pediatr Endocrinol Metab 1997;10:35–40.

    Google Scholar 

  53. Hataya Y, Akamizu T, Takaya K, Kanamoto N, Ariyasu H, Saijo M, Moriyama K, Shimatsu A, Kojima M, Kangawa K, Nakao K. A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. J Clin Endocrinol Metab 2001;86:4552–4555.

    Google Scholar 

  54. Yamazaki M, Nakamura K, Kobayashi H, Matsubara M, Hayashi Y, Kangawa K, Sakai T. Regulational effect of ghrelin on growth hormone secretion from perifused rat anterior pituitary cells. J Neuroendocrinol 2002;14:156–162.

    Google Scholar 

  55. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Oikawa S. Regulation of the ghrelin gene: Growth hormone-releasing hormone upregulates ghrelin mRNA in the pituitary. Endocrinology 2001;142:4154–4157.

    Google Scholar 

  56. Grossman A, Savage MO, Lytras N, Preece MA, Sueiras-Diaz J, Coy DH, Rees LH, Besser GM. Responses to analogues of growth hormone-releasing hormone in normal subjects, and in growth-hormone deficient children and young adults. Clin Endocrinol 1984;21:321–330.

    Google Scholar 

  57. Date Y, Murakami N, Kojima M, Matsukura S, Kangawa K, Nakazato M. Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem Biophys Res Commun 2000;275:477–480.

    Google Scholar 

  58. Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva F, Deghenghi R, Camanni F, Ghigo E. Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 2000;23:493–495.

    Google Scholar 

  59. Lin C, Lin S-C, Chang C-P, Rosenfeld MG. Pit-1–dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth. Nature 1992;360:765–768.

    Google Scholar 

  60. Suhr ST, Rahal JO, Mayo KE. Mouse growth-hormone-releasing hormone: Precursor structure and expression in brain and placenta. Mol Endocrinol 1989;3:1693–1700.

    Google Scholar 

  61. Matsubara S, Sato M, Mizobuchi M, Niimi M, Takahara J. Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues. Endocrinology 1995;136:4147–4150.

    Google Scholar 

  62. Korytko AI, Zeitler P, Cuttler L. Developmental regulation of pituitary growth hormone-releasing hormone receptor gene expression in the rat. Endocrinology 1996;137:1326–1331.

    Google Scholar 

  63. Wajnrajch MP, Chua SC, Green ED, Leibel RL. Human growth hormone releasing hormone receptor (GHRHR) maps to a YAC at Chromosome 7p15. Mammalian Genome 1994;5:595.

    Google Scholar 

  64. Gaylinn BD, von Kap-Herr C, Golden WL, Thorner MO. Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization. Genomics 1994;19:193–195.

    Google Scholar 

  65. Lin SC, Lin CR, Gukovsky I, Lusis AJ, Sawchenko PE, Rosenfeld M. Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 1993;364:208–213.

    Google Scholar 

  66. Mayo KE, Miller TL, DeAlmeida V, Zheng J, Godfrey PA. The growth-hormone-releasing hormone receptor: Signal transduction, gene expression, and physiological function in growth regulation. Ann NY Acad Sci 1996;805:184–203.

    Google Scholar 

  67. Cohen LE. Genetic regulation of the embryology of the pituitary gland and somatotrophs. Endocrine 2000;12:99–106.

    Google Scholar 

  68. Cogan JD, Phillips JA III. Growth disorders caused by genetic defects in the growth hormone pathway. Adv Pediatr 1998;45:337–361.

    Google Scholar 

  69. Mayo KE, Miller T, DeAlmeida V, Godfrey P, Zheng J, Cunha SR. Regulation of the pituitary somatotroph cell by GHRH and its receptor. Recent Prog Horm Res 2000;55:237–266.

    Google Scholar 

  70. Procter AM, Phillips JA, III, Cooper DN. The molecular genetics of growth hormone deficiency. Hum Genet 1998;103:255–272.

    Google Scholar 

  71. Parks JS, Brown MR, Hurley DL, Phelps CJ, Wajnrajch MP. Heritable disorders of pituitary development. J Clin Endocrinol Metab 1999;84:4362–4370.

    Google Scholar 

  72. Seifert H, Perrin M, Rivier J, Vale W. Binding sites for growth hormone releasing factor on rat anterior pituitary cells. Nature 1985;313:487–489.

    Google Scholar 

  73. Lam KS, Lee MF, Tam SP, Srivastava G. Gene expression of the receptor for growth-hormone-releasing hormone is physiologically regulated by glucocorticoids and estrogen. Neuroendocrinology 1996;63:475–480.

    Google Scholar 

  74. Korytko AI, Cuttler L. Thyroid hormone and glucocorticoid regulation of pituitary growth hormone-releasing hormone receptor gene expression. J Endocrinol 1997;152:R13–R17.

    Google Scholar 

  75. Miller TL, Mayo KE. Glucocorticoids regulate pituitary growth hormone-releasing hormone receptor messenger ribonucleic acid expression. Endocrinology 1997;138:2458–2465.

    Google Scholar 

  76. Ono M, Miki N, Murata Y, Osaki E, Tamitsu K, Ri T, Yamada M, Demura H. Sexually dimorphic expression of pituitary growth hormone-releasing factor receptor in the rat. Biochem Biophys Res Commun 1995;216:1060–1066.

    Google Scholar 

  77. Petersenn S, Rasch AC, Heyens M, Schulte HM. Structure and regulation of the human growth hormone-releasing hormone receptor gene. Mol Endocrinol 1998;12:233–247.

    Google Scholar 

  78. Zeitler P, Argente J, Chowen-Breed JA, Clifton DK, Steiner RA. Growth hormone-releasing hormone messenger ribonucleic acid in the hypothalamus of the adult male rat is increased by testosterone. Endocrinology 1990;127:1362–1368.

    Google Scholar 

  79. Jansson JO, Frohman LA. Differential effects of neonatal and adult androgen exposure on the growth hormone secretory pattern in male rats. Endocrinology 1987;120:1551–1557.

    Google Scholar 

  80. Argente J, Chowen JA. Control of the transcription of the growth hormone-releasing hormone and somatostatin genes by sex steroids. Horm Res 1993;40:48–53.

    Google Scholar 

  81. Miki N, Ono M, Murata Y, Ohsaki E, Tamitsu K, Ri T, Demura H, Yamada M. Thyroid hormone regulation of gene expression of the pituitary growth hormone-releasing factor receptor. Biochem Biophys Res Commun 1995;217:1087–1093.

    Google Scholar 

  82. Katakami H, Downs TR, Frohman LA. Decreased hypothalamic growth hormone-releasing hormone content and pituitary responsiveness in hypothyroidism. J Clin Invest 1986;77:1704–1711.

    Google Scholar 

  83. Vale W, Vaughan J, Yamamoto G, Spiess J, Rivier J. Effects of synthetic human pancreatic (tumor) GH releasing factor and somatostatin, triiodothyronine and dexamethasone on GH secretion in vitro. Endocrinology 1983;112:1553–1555.

    Google Scholar 

  84. Cheng TC, Beamer WG, Phillips JA III, Bartke A, Mallonee RL, Dowling C. Etiology of growth hormone deficiency in little, Ames, and Snell dwarf mice. Endocrinology 1983;113:1669–1678.

    Google Scholar 

  85. Chua SC, Hennessey K, Zeitler P, Leibel RL. The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6. Mamm Genome 1993;4:555–559.

    Google Scholar 

  86. Jansson JO, Downs TR, Beamer WG, Frohman LA. Receptor-associated resistance to growth hormone-releasing factor in dwarf “little” mice. Science 1986;232:511–512.

    Google Scholar 

  87. Wajnrajch MP, Gertner JM, Harbison MD, Chua SC, Leibel RL. Nonsense mutation in the human growth hormone releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Nat Genet 1996;12:88–90.

    Google Scholar 

  88. Maheshwari H, Silverman BL, Dupuis J, Baumann G. Dwarfism of Sindh: A novel form of familial isolated GH deficiency linked to the locus for the GH releasing hormone receptor. In: International Conference on Endocrinology. San Francisco, CA: Endocrine Society, 1996.

    Google Scholar 

  89. Netchine I, Talon P, Dastot F, Vitaux F, Goosens M, Amselem S. Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene. J Clin Endocrinol Metab 1998;83:432–436.

    Google Scholar 

  90. Salvatori R, Hayashida CY, Aguiar-Oliveira MH, Phillips JAR, Souza AH, Gondo RG, Toledo SP, Conceicao MM, Prince M, Maheshwari HG, Baumann G, Levine MA. Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene. J Clin Endocrinol Metab 1999;84:917–923.

    Google Scholar 

  91. Salvatori R, Fan X, Phillips JA III, Prince M, Levine MA. Isolated growth hormone (GH) deficiency due to compound heterozygosity for two new mutations in the GH-releasing hormone receptor gene. Clin Endocrinol 2001;54:681–687.

    Google Scholar 

  92. Salvatori R, Fan X, Phillips JA III, Prince M, Levine MA. Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type 1b. J Clin Endocrinol Metab 2001;86:273–279.

    Google Scholar 

  93. Mayo KE, Hammer RE, Swanson LW, Brinster RL, Rosenfeld MG, Evans RM. Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene. Mol Endocrinol 1988;2:606–612.

    Google Scholar 

  94. Adams EF, Symowski H, Buchfelder M, Poyner DR. A polymorphism in the growth hormone (GH)-releasing hormone (GHRH) receptor gene is associated with elevated response to GHRH by human pituitary somatotrophinomas in vitro. Biochem Biophys Res Commun 2000;275:33–36.

    Google Scholar 

  95. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 1989;340:692–696.

    Google Scholar 

  96. Hashimoto K, Koga M, Motomura T, Kasayama S, Kouhara H, Ohnishi T, Arita N, Hayakawa T, Sato B, Kishimoto T. Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas. J Clin Endocrinol Metab 1995;80:2933–2939.

    Google Scholar 

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Lin-Su, K., Wajnrajch, M.P. Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor . Rev Endocr Metab Disord 3, 313–323 (2002). https://doi.org/10.1023/A:1020949507265

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  • GHRH
  • GHRH receptor (GHRHR)