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Predicting the Time Needed to Achieve Steady State If Absorption and Elimination Constants Are Equal

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Abstract

A simple table is derived to facilitate the rapid estimation of the number of dose administrations needed to achieve a certain fraction of the steady-state plasma concentration in the case of one-compartment model with uniform multiple oral dosing and equal absorption and elimination constants.

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REFERENCES

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Authors and Affiliations

  1. Clinical Research and Development, Chinoin Pharmaceutical and Chemical Works Ltd., H-1045, Budapest, Tó u 1-5, Hungary

    Júlia Singer

  2. Chemical Research Center, Institute of Chemistry, Hungarian Academy of Sciences, H-1525, Budapest, P.O.Box 17, Hungary

    László Vereczkey

Authors
  1. Júlia Singer
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  2. László Vereczkey
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Singer, J., Vereczkey, L. Predicting the Time Needed to Achieve Steady State If Absorption and Elimination Constants Are Equal. J Pharmacokinet Pharmacodyn 27, 297–300 (1999). https://doi.org/10.1023/A:1020947130038

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  • DOI: https://doi.org/10.1023/A:1020947130038

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