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Design and synthesis of artificial ribonucleases based on 1,4-diazabicyclo[2.2.2]octane and imidazole

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Russian Chemical Bulletin Aims and scope

Abstract

The review surveys the results of our studies devoted to the design of highly efficient catalysts of hydrolysis of the phosphodiester bonds in RNA. These catalysts contain the imidazole residue in the catalytic domain, one or several bis-quaternized rings of 1,4-diazabicyclo[2.2.2]octane as a polycationic RNA-binding domain, and a lipophilic radical. A versatile approach to artificial ribonucleases of this type was proposed, which allows one to vary not only the number of positive charges in the RNA-binding domain, the structure of the catalytic site, and their mutual arrangement but also the domain structure of the molecule as a whole. Analysis of the catalytic properties of the synthesized constructs makes it possible to optimize the domain structure and the geometry of the molecule ensuring its maximum ribonuclease activity.

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Authors and Affiliations

  1. Siberian Branch of the Russian Academy of Sciences, Novosibirsk Institute of Bioorganic Chemistry, 8 prosp. Akad. Lavrent"eva, 630090, Novosibirsk, Russian Federation

    D. A. Konevetz, G. V. Shishkin, V. V. Vlassov & V. N. Silnikov

  2. Siberian Branch of the Russian Academy of Sciences, G. K. Boreskov Institute of Catalysis, 5 prosp. Akad. Lavrent"eva, 630090, Novosibirsk, Russian Federation

    I. E. Beck

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  1. D. A. Konevetz
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  2. I. E. Beck
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  3. G. V. Shishkin
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  4. V. V. Vlassov
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  5. V. N. Silnikov
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Konevetz, D.A., Beck, I.E., Shishkin, G.V. et al. Design and synthesis of artificial ribonucleases based on 1,4-diazabicyclo[2.2.2]octane and imidazole. Russian Chemical Bulletin 51, 1100–1111 (2002). https://doi.org/10.1023/A:1020937505019

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