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10-23 DNA enzymes for targeting MDR1 mRNA

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Abstract

The properties of the 31-mer 10-23 DNA enzyme and its analog with the terminal 3"-3" internucleotide linkage, which are complementary to an mRNA region of the multi-drug resistance gene MDR1, were investigated. DNA enzymes can selectively cleave RNA with high efficiency in a catalytic mode as exemplified by a synthetic 18-mer fragment of MDR1 mRNA.

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Authors and Affiliations

  1. Novosibirsk Institute of Bioorganic Chemistry, 8 prosp. Akad. Lavrent"eva, 630090, Novosibirsk, Russian Federation

    M. A. Kuznetsova, M. N. Repkova, A. G. Venyaminova & V. V. Vlassov

  2. Novosibirsk State University, 2 ul. Pirogova, 630090, Novosibirsk, Russian Federation

    A. A. Fokina

Authors
  1. M. A. Kuznetsova
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  2. M. N. Repkova
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  3. A. A. Fokina
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  4. A. G. Venyaminova
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  5. V. V. Vlassov
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Kuznetsova, M.A., Repkova, M.N., Fokina, A.A. et al. 10-23 DNA enzymes for targeting MDR1 mRNA. Russian Chemical Bulletin 51, 1190–1193 (2002). https://doi.org/10.1023/A:1020936110045

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  • DOI: https://doi.org/10.1023/A:1020936110045

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