Abstract
A novel class of nano-hybrid materials, “Cerasome,” bearing a liposomal bilayer structure and a ceramic surface, has been developed by a sol-gel reaction of a double-chain proamphiphile having an trialkoxysilane in the head moiety and followed self-assembling. In the present work, we developed new methods for preparation of the Cerasomes forming under various pH conditions and their surface modification by employing appropriate alkoxysilane compounds. When the proamphiphilic alkoxysilane was hydrolyzed in an acidic ethanol and then injected into an aqueous media at various pH, the morphologically stable Cerasomes were obtained in a wide pH range. On the other hand, an acid treatment of the proamphiphile in ethanol in the presence of tetraethoxysilane gave the Cerasome with highly developed siloxane networks on its vesicular surface. Surface modification of the Cerasome with amino groups was readily achieved in the similar manner by replacing tetraethoxysilane to 3-aminopropyltriethoxysilane. The Cerasomes thus prepared were characterized by means of dynamic light scattering and zeta potential measurements.
Similar content being viewed by others
References
C. Sanchez and F. Ribot, New J. Chem. 18, 1007 (1994).
J.D. Mackenzie, J. Sol-Gel Sci. Technol. 2, 81 (1994).
C.J. Brinker and G.W. Scherer, Sol-Gel Science; The Physics and Chemistry of Sol-Gel Processing (Academic Press, San Diego, 1990).
A.C. Pierre, Introduction to Sol-Gel Processing (Kluwer Academic Publishers, Boston, 1998).
T. Yanagisawa, T. Shimizu, K. Kuroda, and C. Kato, Bull. Chem. Soc. Jpn. 63, 988 (1990).
C.T. Kresge, M.E. Leonowicz, W.J. Roth, J.C. Vartuli, and J.S. Beck, Nature 359, 710 (1992).
M. Ogawa, J. Am. Chem. Soc. 116, 7941 (1994).
K. Sakata and T. Kunitake, J. Chem. Soc., Chem. Commun. 504 (1990).
Y. Ono, K. Nakashima, M. Sano, Y. Kanekiyo, K. Inoue, J. Hojo, and S. Shinkai, Chem. Commun. 1477 (1998).
J.H. Jung, Y. Ono, and S. Shinkai, Langmuir 16, 1643 (2000).
K. Katagiri, K. Ariga, and J. Kikuchi, Chem. Lett. 661 (1999).
K. Ariga, K. Katagiri, and J. Kikuchi, Kobunshi Ronbunshu 57, 251 (2000).
K. Katagiri, K. Ariga, and J. Kikuchi, in Studies in Surface Science and Catalysis, edited by Y. Iwasawa, N. Oyama, and H. Kunieda (Elsevier Science B.V., Amsterdam, 2001), Vol. 132, p. 599.
K. Katagiri, R. Hamasaki, R. Hamasaki, K. Ariga, and J. Kikuchi, J. Am. Chem. Soc. 124, 7892 (2002).
A.D. Bangham and R.W. Horne, J. Mol. Biol. 8, 660 (1964).
G. Sessa and G. Weissmann, J. Biol. Chem. 243, 4364 (1968).
Y. Murakami and J. Kikuchi, in Bioorganic Chemistry Frontiers, edited by H. Dugas (Springer-Verlag, Berlin, 1991), Vol. 2, p. 73.
J.N. Israelachvili, S. Marcelja, and R.G. Horn, Quart. Rev. Biophys. 13, 121 (1980).
D.J. Mitchell and B.W. Ninham, J. Chem. Soc., Faraday Trans. 772, 601 (1981).
H. Nishimori, M. Tatsumisago, and T. Minami, Bull. Chem. Soc. Jpn. 69, 815 (1996).
Rights and permissions
About this article
Cite this article
Katagiri, K., Hamasaki, R., Ariga, K. et al. Preparation and Surface Modification of Novel Vesicular Nano-Particle “Cerasome” with Liposomal Bilayer and Silicate Surface. Journal of Sol-Gel Science and Technology 26, 393–396 (2003). https://doi.org/10.1023/A:1020781400998
Issue Date:
DOI: https://doi.org/10.1023/A:1020781400998