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Intrastriatal Injection of 5,7-Dihydroxytryptamine Decreased 5-HT Levels in the Striatum and Suppressed Locomotor Activity in C57BL/6 Mice

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Abstract

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 5,7-dihydroxytryptamine (5,7-DHT) on striatal levels of dopamine (DA), 5-hydroxytryptamine (5-HT), and their metabolites, as well as on locomotor activity were investigated in C57BL/6 mice. The results showed that MPTP significantly increased locomotor activity and decreased striatal DA levels. However, injection of the serotonergic neurotoxin 5,7-DHT in the striatum, either alone or following high doses of MPTP, significantly decreased locomotor activity, and concomitantly decreased striatal levels of 5-HT and 5-HIAA. This study suggests that the increased locomotor activity may be due to increased striatal serotonergic activity which overcompensates for the DA deficiency. The locomotor hypoactivity, induced by 5,7-DHT, might be due to the decreased striatal levels of 5-HT and 5-HIAA.

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Authors and Affiliations

  1. Section of Neurology, Taichung Veterans General Hospital, Taichung, (407), Taiwan

    Lie-Gan Chia, Dah-Ren Ni & Yuh-Pin Ho

  2. Department of Medical Research, Taichung Veterans General Hospital, Taichung, (407), Taiwan

    Fu-Chou Cheng & Jon-Son Kuo

  3. Section of Neurology, National Yang-Ming University, Taipei, (112), Taiwan

    Lie-Gan Chia

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  1. Lie-Gan Chia
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  2. Dah-Ren Ni
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Chia, LG., Ni, DR., Cheng, FC. et al. Intrastriatal Injection of 5,7-Dihydroxytryptamine Decreased 5-HT Levels in the Striatum and Suppressed Locomotor Activity in C57BL/6 Mice. Neurochem Res 24, 719–722 (1999). https://doi.org/10.1023/A:1020771211305

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