Abstract
Investigation of [35S]GTPγS binding with G proteins in plasma membranes of the molluscan nervous system demonstrated the existence of an inverse agonism phenomenon for dopamine.
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REFERENCES
A. G. Gilman, “G proteins: transducer of receptor-generated signals,” Annu. Rev. Biochem., 56, 615–649 (1987).
R. Leurs, M. J. Smit, A. E. Alewijnse, and H. Timmerman, “Agonist-independent regulation of constitutively active G-protein-coupled receptors,” Trends Biochem. Sci., 23, 418–422 (1998).
I. M. Prudnikov, O. N. Osipenko, T. F. Kastrikina, and V. N. Tsyvkin, “Dopamine effect on ionic conduction and adenyl cyclase activity in the central nervous system of the pond snail,” Neirofiziologiya, 24, 437–450 (1992).
I. M. Prudnikov, “Guanine nucleotide-induced enhancement of affinity of dopaminergic membrane receptors of nerve tissues of Lymnaea stagnalis for agonists,” Neurophysiology/Neirofiziologiya, 25, 271–278 (1993).
I. M. Prudnikov and V. N. Tsyvkin, “Membranes with dopamine receptors coupled to G proteins: purification from the Lymnaea central nervous system,” Neurophysiology/Neirofiziologiya, 30, 41–48 (1998).
H. K. Happe, D. B. Bylund, and L. C. Murrin, “Agonist-stimulated [35S] GTPγS autoradiography: optimization for high sensitivity,” Eur. J. Pharm., 422, 1–13 (2001).
I. M. Prudnikov and V. N. Tsyvkin, “Agonist dependent attenuation of GTPase activity of G proteins coupled to dopamine receptors in the molluscan nervous system,” Neurophysiology/Neirofiziologiya, 30, 104–112 (1998).
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Prudnikov, I., Tsyvkin, V. Dopamine Is a Natural Inverse Agonist in the Lymnaea Nervous System. Neurophysiology 34, 207–209 (2002). https://doi.org/10.1023/A:1020767703683
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DOI: https://doi.org/10.1023/A:1020767703683