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Regulation by Delta-Sleep-Inducing Peptide of the Neurochemical Changes in the Brain Associated with Dopaminergic System Hyperactivity

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Abstract

The influence of a single injection of “delta-sleep-inducing peptide” (DSIP; 30 μg/kg body weight) on neurochemical parameters of rats' brain was studied under the conditions of chronic administration of dopamine analogs inducing DA-system hyperactivity – 50 mg/kg body weight of L-DOPA for 30 days or 2,5 mg/kg body weight of amphetamine for 21 days. The parameters of serotonergic system (MAO A activity, 5-HT, and 5-HIAA contents) and of dopaminergic system (MAO B activity, DA, NA, and HVA contents) were investigated in the cortex and caudate nucleus of control, DA or amphetamine, and DSIP receiving rats. Changes caused by the two DA-system activating drugs had both similarities and differences, and the corrective action of DSIP also had certain peculiarities depending on the pharmacological preparation used for the induction of DA-system hyperactivity and on the investigated brain structure. It is supposed that DSIP action might be based on the activation of serotonergic system that ensures the adaptive behavior of the animals.

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REFERENCES

  1. Olson, G. A., Olson, R. D., and Kastin, A. J. 1986. Endogenous opiates. Peptides. 7:907-933.

    Google Scholar 

  2. Graf, M. V., Schoenenberger, G. A. 1985. DSIP an adrenergic modulator? Biol. Chem. Hoppe-Seyler. 366:795.

    Google Scholar 

  3. Nakamura, A., and Shiomi, N. 1990. Possible role of delta-sleep inducing peptide (DSIP) as an endogenous pain modulator. Neurosci. Res. Suppl. 11:4.

    Google Scholar 

  4. Graf, M., Baumann, J. B., Girard, I., Tobler, H. J., and Schoenenberger, G. A. 1982. DSIP-induced changes of the daily concentrations of brain neurotransmitters and plasma proteins in rats. Pharmacol. Biochem. Behav. 17:541-547.

    Google Scholar 

  5. Ashmarin, I. P. 1984. Perspectives of the practical application of some results of basic research in the field of small regulatory peptides. Voprosy Med. Khimii. 30(No.3):2-7 (in Russian).

    Google Scholar 

  6. Dovedora, E. L., Popova, N. S., and Katchalova, L. M. 1983. Effects of delta-sleep-inducing peptide on the activities of monoamine oxidase, acetylcholinesterase, and bioelectric activity of the motor structures of the brain. Neurochemistry (Yerevan). 2:138-148 (in Russian).

    Google Scholar 

  7. Sudakov, K. V., Ivanov, V. T., Koplik, E. V., Vedjaev, D. T., Michaleva, I. I., and Sargsian, F. S. 1983. Delta-sleep inducing peptide (DSIP) as a factor facilitating animals' resistance to acute emotional stress. Pavlov J. Biol. Sci. 18:1-5.

    PubMed  Google Scholar 

  8. Kryjanovsky, G. N., Shandra, A. A., Godlevsky, L. S., Karpov, M. N., Mikhaleva, I. I., and Ivanov, V. T. 1987. Influence of delta-sleep-inducing peptide on the epileptic activity in the cortex of rats' and cats' brain. Bulletin Exp. Biol. Med. 114:582-585.

    Google Scholar 

  9. Mendgeritsky, A. M., Makletsova, M. G., Uskova, I. I., Tchorayan, I. O., and Mikhaleva, I. I. 1991. Antistressory effect of delta-sleep-inducing peptide in hypokinetic stress. Ukr. Biochim. J. 63:34-37 (in Russian).

    Google Scholar 

  10. Lynch, M. R. 1992. Schizophrenia and the D1-receptor: focus on negative symptoms. Progr. Neuro-Psychopharmacol. Biol. Psychiat. 16:797-832.

    Google Scholar 

  11. Popova, N. S., Dovedova, E. L., and Adrianov, O. S. 1987. Systemic, cellular and molecular rearrangements caused by the action of peptides with different opioid activity. I. M. Setchenov Physiol. Journal of the USSR. LXXIII:730-737 (in Russian).

    Google Scholar 

  12. Biesold, D. 1967. Biochemistry and the function of nervous system. Pages 115-122. Nauka. Leningrad (in Russian).

    Google Scholar 

  13. Popov, N., Rosler, V., Thiemann, C., and Matthies, H. 1971. Eine empfindliche Methode zur Bestimmung der Monoaminoxydase-Aktivitat im Gewebe durch Aldehydsemikarbazon-Messung. Acta Biol. Med. Germ. 26:237-241.

    Google Scholar 

  14. Gorkin, V. Z., Verevkina, A. V. Gridneva, L. I., Jerdeva, L. V., Klyashtorin, L. B., and Krivtchenkova, R. S. 1968. The methods of the study of activity and specificity of inhibition of MAO in mitochondria. Pages 155-177, in Modern methods in biochemistry, vol. 2, Meditsina, Moscow (in Russian).

    Google Scholar 

  15. Kogan, B. M., and Netchaev, N. V. 1979. Sensitive and rapid method of simultaneous determination of DA, NA, 5-HT and 5-hydroxyindolacetic acid in one sample. Labor. Delo. 5301-303 (in Russian).

  16. Anden, N. E., Ross, B. T., and Werdinius, B. (1963. On the occurrence of homovanillic acid in brain and cerebral spinal fluid and its determination by a fluorometric metod. Life Sci. 2:448-458.

    Google Scholar 

  17. Gershtein, L. M., and Dovedova, E. L. 1994. Multiple-level neurochemical organization of the brain as one of the possibilities of CNS adaptation during extreme influences. Vestnik AMN. No. 1:30-34 (in Russian).

    Google Scholar 

  18. Dluzen, D. E., and Ramirez, V. P. 1987. 《In vivo》 release of dopamine and its metabolites following a direct infusion of L-DOPA into the caudate nucleus of awaked freely behaving rats using a push-pull cannula. Neurosci. Lett. 82:29-34.

    PubMed  Google Scholar 

  19. Popova, N. S., Dovedova, E. L., Veslov, R., and Yankovitch, B. 1989. Functional and biochemical rearrangements under the conditions of dopaminergic system hyperfunction. I. M. Setchenov Physiol. Journal of the USSR. 75:1075-1081 (in Russian).

    Google Scholar 

  20. Popova, N. S., and Dovedova, E.L. 1998. Amphetamine-induced hyperfunction of dopaminergic system and delta-sleep-inducing peptide. Russian I. M.Setchenov Physiol. Journal. 84:24-29 (in Russian).

    Google Scholar 

  21. Dovedova, E. L., and Ashmarin, I. P. 1982. In vivo effects of delta-sleep-inducing peptide on the activities of monoamine oxidase and acetylcholinesterase in subcellular fractions from different formations of rabbit brain. Bulletin Exp. Biol. Med. 93:56-58 (in Russian).

    Google Scholar 

  22. Katchalova, L. M., and Popova, N. S. 1987. Principles of the rearrangement of the functional interrelations of brain structures during the influence on dopamine system. J. Vysch. Nervn. Deyat. 37:97-106 (in Russian).

    Google Scholar 

  23. Gromova, E. A. 1979. Functional interrelations of CA and serotonergic systems of the brain—antagonism or reciprocity? Pages 97-105, in: “CA neurons”, Moscow (in Russian).

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Authors and Affiliations

  1. Laboratory of Cytochemistry, Brain Research Institute of the Russian Academy of Medical Sciences, Moscow, Russia

    L. M. Gershtein & E. L. Dovedova

  2. Laboratory of Cytochemistry, Brain Research Institute of the Russian Academy of Medical Sciences. Pereulok Obukha, Moscow, Russia

    L. M. Gershtein

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  1. L. M. Gershtein
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  2. E. L. Dovedova
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Gershtein, L.M., Dovedova, E.L. Regulation by Delta-Sleep-Inducing Peptide of the Neurochemical Changes in the Brain Associated with Dopaminergic System Hyperactivity. Neurochem Res 24, 1135–1141 (1999). https://doi.org/10.1023/A:1020760303553

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