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Localization of the Repetitive Firing Generation Site Induced by 4-Aminopyridine at the Frog Neuromuscular Junction

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Abstract

In the neuromuscular junction, blockade of potassium channels can produce multiple discharges after single nerve stimulation. Multielectrode recording from the nerve trunk and myelinated and non-myelinated parts of the nerve ending demonstrated that repetitive presynaptic spikes elicited by 4-aminopyridine arise earliest within the part of the axon proximal to the motor nerve ending.

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REFERENCES

  1. J. Molgo, M. Lemeignan, and P. Lechat, “Changes in transmitter release at frog neuromuscular junction induced by 4-aminopyridine,” C. R. Acad. Sci., Ser. D, 281,No. 21, 1637–169 (1975).

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  2. R. A. Giniatullin, “Repetitive firing in motor nerve endings: modulation by divalent cations, rhythmic activation, and cholinergic agents,” Neirofiziologiya, 24,No. 4, 387–395 (1992).

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Authors and Affiliations

  1. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Republic of Tatarstan, Russia

    D. V. Samigullin & E. E. Nikolsky

  2. Kazan State Medical University, Republic of Tatarstan, Russia

    R. A. Afzalov, R. A. Giniatullin & E. E. Nikolsky

Authors
  1. D. V. Samigullin
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  2. R. A. Afzalov
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  3. R. A. Giniatullin
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  4. E. E. Nikolsky
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Correspondence to D. V. Samigullin.

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Samigullin, D.V., Afzalov, R.A., Giniatullin, R.A. et al. Localization of the Repetitive Firing Generation Site Induced by 4-Aminopyridine at the Frog Neuromuscular Junction. Neurophysiology 34, 222 (2002). https://doi.org/10.1023/A:1020728022339

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  • DOI: https://doi.org/10.1023/A:1020728022339

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