Abstract
The pair-coupled amino acid composition is introduced to predict the secondary structure contents of a protein. Compared with the existing methods all based on singlewise amino acid composition as defined in a 20D (dimensional) space, this represents a step forward to the consideration of the sequence coupling effect. The test results indicate that the introduction of the pair-coupled amino acid composition can significantly improve the prediction quality. It is anticipated that the concept of the pair-coupled amino acid composition can be used to simplify the formulation of sequence coupling (or sequence order) effects and to study many other features of proteins as well.
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Chou, KC. Using Pair-Coupled Amino Acid Composition to Predict Protein Secondary Structure Content. J Protein Chem 18, 473–480 (1999). https://doi.org/10.1023/A:1020696810938
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DOI: https://doi.org/10.1023/A:1020696810938