Abstract
A skin–air model is developed to model the water barrier function of skin. The skin model is a porous solid saturated with a monovalent salt solution. The air model is a vapor diffusion model in non-moving air. In vivo measurements of water loss from human skin under varying ambient conditions are used to validate the model.
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Anderson, R., Cassidy, J., Hansen, J. and Yellin, W.: 1973, Hydration of stratum corneum, Biopolym. 12, 2789–2802.
de Borst, R., Kusters, G., Nauta, P. and Witte, F. D.: 1985, DIANA - A comprehensive, but flexible finite element system, In: C. Brebbia (ed.), Finite Element Systems: A Handbook, Springer Verlag, Berlin, New York and Tokyo.
DIANA: 1996, DIANA Finite Element Analysis: User's Manual, TNO Building and Construction Research, Delft, The Netherlands.
El-Shimi, A. and Princen, H.: 1978, Water vapor sorption and desorption behavior of some keratins, Colloid Polym. Sci. 256, 105–114.
Fatt, I.: 1968, Dynamics of water transport in the corneal stroma, Exp. Eye Res. 7, 402–412.
Guyton, A. and Hall, J.: 1996, Textbook of Medical Physiology,W.B. Saunders Company, New York.
Hansen, J. and Yellin, W.: 1972, NMR and infrared spectroscopic studies of stratum corneum hydration, In: H. Jellinek (ed.), Water Structure at the Water-Polymer Interface, Plenum Press, New York.
Hilliard Jr., P. and Dorogi, P.: 1989, Investigation of temperature and water activity effects on pig skin in vitro, J. Soc. Cosmet. Chem. 40, 1–20.
Holbrook, K. and Odland, G.: 1974, Regional differences in the thickness (cell layers of the human stratum corneum: an ultrastructural analysis, J. Invest. Dermatol. 62, 415–422.
Huyghe, J. and Janssen, J.: 1997, Quadriphasic mechanics of swelling incompressible porous media, Int. J. Eng. Sci. 35, 793–802.
Kemenade, P.: 1998, Water and ion transport through the skin, PhD Thesis, Eindhoven University of Technology, The Netherlands.
Lai, W., Hou, J. and Mow, V.: 1991, A triphasic theory for the swelling and deformation behaviors of articular cartilage, J. Biomech. Eng. 113, 245–258.
Langer, A.: 1861, Zur Anatomie und Physiologie der Haut. 1. Uber die Spaltbarkeit der Cutis, S.B. Akad. Wien 44, 19–46.
Mackie, J. and Meares, P.: 1955, Diffusion of electrolytes in cation exchange resin, Proc. Res. Soc. London Der. A 232, 498.
Maroudas, A.: 1975, Biophysical chemistry of cartilaginous tissues with special reference to solute and fluid transport, Biorheol. 12, 232–248.
Marshall, T.: 1988, Soil Physics, 2nd edn., Cambridge University Press.
Nachemson, A.: 1981, Disc pressure measurements, Spine 6, 93–97.
Nitao, J. and Bear, J.: 1996, Potentials and their role in transport in porous media, Water Resour. Res. 32(2), 225–250.
Oomens, C.: 1985, A mixture approach to the mechanics of skin and subcutis, PhD Thesis, University of Twente.
Oomens, C., Campen, D. V. and Grootenboer, H.: 1987, A mixture approach to the mechanics of skin, J. Biomech. 20(9), 877–885.
Oomens, C., de Heus, H., Huyghe, J., Nelissen, L. and Janssen, J.: 1995, Validation of the triphasic mixture theory for a mimic of intervertebral disc tissue, Biomimetics 3, 171–185.
Park, A. and Baddiel, C.: 1972, Rheology of stratum corneum-I: a molecular interpretation of the stress-strain curve, J. Soc. Cosmet. Chem. 23, 3–12.
Pikal, M. and Shah, S.: 1990, Transport mechanisms in iontophoresis. III. An experimental study of the contributions of electro-osmotic flow and permeability change in transport of solutes, Pharm. Res. 7(3), 222–229.
Snijders, H., Huyghe, J. and Janssen, J.: 1995, Triphasic finite element model for swelling porous media, Int. J. Num. Meth. Fluids 20, 1039–1046.
Snijders, J.: 1994, The triphasic mechanics of the intervertebral disc - a theoretical, numerical and experimental analysis, PhD Thesis, University of Limburg, Maastricht, The Netherlands.
Spencer, T., Linamen, C., Akers, W. and Jones, H.: 1975, Temperature dependence of water content of stratum corneum, Br. J. Dermatol. 93, 159–164.
Swabb, E., Wei, J. and Gullino, P.: 1974, Diffusion and convection in normal and neoplastic tissues, Cancer Res. 34, 2814–2822.
Warner, R., Meyers, M. and Taylor, D.: 1988, Electron probe analysis of human skin: determination of the water concentration profile, J. Invest. Dermatol. 90, 218–224.
Whitton, J. and Everall, J.: 1973, The thickness of the epidermis, Br. J. Dermatol. 89, 467–476.
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van Kemenade, P.M., Huyghe, J.M. & Douven, L.F.A. Triphasic FE Modeling of the Skin Water Barrier. Transport in Porous Media 50, 93–109 (2003). https://doi.org/10.1023/A:1020680811437
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DOI: https://doi.org/10.1023/A:1020680811437