Abstract
Polymeric derivatives of plant growth regulators (phytoactive polymers) demonstrate their biological activity after releasing the low-molecular-weight bioactive substances by hydrolysis. In the present work the release rates for a series of polymeric esters of carboxyl-containing plant growth regulators of the auxin group (2,4-dichlorophenoxy acetic acid, 1-naphthylacetic acid, 2-naphthoxyacetic acid, and 2-naphthylthioacetic acid) were studied. The effective rateconstants in experiments of alkaline hydrolysis decreased as the molecular mass of the polymer increased, the content of acid hydrophobic residues in polymer increased, and the acidity of the acid decreased. Data on the elucidation of stucture versus release-rate relationships in polymeric esters of plant growth regulators will further aid the preparation of novel delivery systems with optimal biological activity.
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References
M. I. SHTILMAN, in “Immobilization on Polymers” (VSP, Utrecht-Tokyo, 1993).
A. M. TSATSAKIS and M. I. SHTILMAN, Plant Growth Regul. 14 (1994) 69.
Idem., in “Morphogenesis of Plants. Molecular Approaches, ” edited by K. A. Roubelakis-Angelakis and K. Tran Thanh Kan (Plenum Press, New York, 1993) p. 259.
M. I. SHTILMAN, Vysokomol Soedin Ser. B 37 (1995) 902.
A. K. RIZOS, A. M. TSATSAKIS, M. I. SHTILMAN and W. BROWN, Polymer 39 (1998) 4729.
Idem., J. Non-Cryst. Solids 235–237 (1998) 652.
Idem., Polymer 39 (1998) 1753.
G. G. ALLAN, M. J. COUSIN and R. A. MIKELS, Amer. Chem. Soc. Polym. Prepr. 20 (1979) 341.
G. G. ALLAN, A. STOJANOV and M. UEDA, in Proc. CRS Symp. Bioact. Mater., Vol. 19, edited by J. Kopecek (CRS Press, Derfield, IL, 1992) p. 178.
C. L. MCCORMICK, K. W. ANDERSON and B. H. HUTHINSON, J. Macromol. Sci. Chem. C 22 (1983) 57.
F. W. HARRIS, M. R. DYKES, J. A. BAKER and A. F. ALABAUGH, ACS Symp. Ser., Vol. 53: Controlled Release Pestic (American Chamical Society, Washington DC, 1977) p. 102.
C. L. MCCORMICK, KIMKI SOO and S. A. EZZELL, J. Control. Release 72 (1998) 101.
M. I. SHTILMAN, M. YA. KORNAKOV, A. M. TSATSAKIS, N. V. KURUSHINA and T. P. ZALUKAEVA, Vysokomol Soedin (Polymer Science), Ser. A 34 (1992) 17.
A. M. TSATSAKIS, I. M. SHASHKOVA and M. I. SHTILMAN, Vysokomol. Soed., Ser. B 34 (1992) 32.
M. I. SHTILMAN, M. B. SARKISYAN, A. M. TSATSAKIS, I. M. SHASHKOVA and P. DAIS, Vysokomol Soedin (Polymer Science), Ser. A 37 (1995) 22.
J. BRANDRUP and E. N. IMMERGUT (eds.), “Polymer Handbook” (Wiley, New York, 1989).
H. P. FRANK and G. B. LEVY, J. Polymer Sci. 10 (1953) 371.
YU. S. LIPATOV, A. E. NESTEROV, T. M. GRISHEHENKO and R. A. VESELOVSKII, “A Handbook of Polymer Chemistry” (Naukova Dumka, Kiev, 1971) (in Russian).
V. V. KORSHAK, M. I. SHTILMAN, I. V. YAROSHENKO and T. A. BESTUZHEVA, Vysokomol. Soed., Ser. B 19 (1977) 734 (in Russian).
J. GUILLET, “Polymer Photophysics and Photochemistry” (Cambridge University, 1985).
M. T. BEHME and E. H. CORDES, J. Organic Chem. 29 (1964) 1255.
H. MORAWETZ and P. E. ZIMMERMAN, J. Phys. Chem. 58 (1954) 753.
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Shtilman, M.I., Tsatsakis, A.M., Alegakis, A.K. et al. Structure vs release-rate relationships in polymeric esters of plant growth regulators. Journal of Materials Science 37, 4677–4682 (2002). https://doi.org/10.1023/A:1020673004933
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DOI: https://doi.org/10.1023/A:1020673004933